Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고성호 | - |
dc.date.accessioned | 2021-05-14T00:56:04Z | - |
dc.date.available | 2021-05-14T00:56:04Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, no. 7, article no. 2273 | en_US |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://www.mdpi.com/1422-0067/21/7/2273 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162031 | - |
dc.description.abstract | Regeneration of adult neural circuits after an injury is limited in the central nervous system (CNS). Heme oxygenase (HO) is an enzyme that produces HO metabolites, such as carbon monoxide (CO), biliverdin and iron by heme degradation. CO may act as a biological signal transduction effector in CNS regeneration by stimulating neuronal intrinsic and extrinsic mechanisms as well as mitochondrial biogenesis. CO may give directions by which the injured neurovascular system switches into regeneration mode by stimulating endogenous neural stem cells and endothelial cells to produce neurons and vessels capable of replacing injured neurons and vessels in the CNS. The present review discusses the regenerative potential of CO in acute and chronic neuroinflammatory diseases of the CNS, such as stroke, traumatic brain injury, multiple sclerosis and Alzheimer's disease and the role of signaling pathways and neurotrophic factors. CO-mediated facilitation of cellular communications may boost regeneration, consequently forming functional adult neural circuits in CNS injury. | en_US |
dc.description.sponsorship | This paper was supported by the National Research Foundation of Korea (NRF) grant (2019R1F1A1040463) funded by the Korea Government. This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C2160). | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | carbon monoxide | en_US |
dc.subject | neurogenesis | en_US |
dc.subject | angiogenesis | en_US |
dc.subject | regeneration | en_US |
dc.subject | stroke | en_US |
dc.subject | traumatic brain injury | en_US |
dc.subject | multiple sclerosis | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | central nervous system | en_US |
dc.title | Regenerative Potential of Carbon Monoxide in Adult Neural Circuits of the Central Nervous System. | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 21 | - |
dc.identifier.doi | 10.3390/ijms21072273 | - |
dc.relation.page | 1-23 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.contributor.googleauthor | Jung, Eunyoung | - |
dc.contributor.googleauthor | Koh, Seong-Ho | - |
dc.contributor.googleauthor | Yoo, Myeongjong | - |
dc.contributor.googleauthor | Choi, Yoon Kyung | - |
dc.relation.code | 2020050347 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | ksh213 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.