Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김계성 | - |
dc.date.accessioned | 2021-05-11T05:25:23Z | - |
dc.date.available | 2021-05-11T05:25:23Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 43, no. 3, page. 203-214 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2020.2289 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/161975 | - |
dc.description.abstract | Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology. | en_US |
dc.description.sponsorship | This research was supported by a grant from National Research Foundation of Korea (2018M3A9H3022412 and 20 17R1A2B2008727) and Medical Research Center (2017 R1A5A2015395), funded by the National Research Foundation of Korea (NRF) of the Ministry of Science, ICT and Future Planning, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | deubiquitinating enzyme inhibitors | en_US |
dc.subject | epilepsy | en_US |
dc.subject | neural stem cells | en_US |
dc.subject | Parkinson's disease | en_US |
dc.title | Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 43 | - |
dc.identifier.doi | 10.14348/molcells.2020.2289 | - |
dc.relation.page | 203-214 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Das, Soumyadip | - |
dc.contributor.googleauthor | Ramakrishna, Suresh | - |
dc.contributor.googleauthor | Kim, Kye-Seong | - |
dc.relation.code | 2020053400 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOMEDICAL SCIENCE | - |
dc.identifier.pid | ks66kim | - |
dc.identifier.orcid | https://orcid.org/0000-0001-5550-1660 | - |
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