Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박종은 | - |
dc.date.accessioned | 2021-05-06T06:44:51Z | - |
dc.date.available | 2021-05-06T06:44:51Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | Journal of Alzheimer's Disease, v. 71, no. 1, page. 7-13 | en_US |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad190469 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/161904 | - |
dc.description.abstract | Alzheimer's disease patients with presenilin 1 (PSEN1) mutations commonly show parkinsonism in addition to dementia. Yet, whether these patients show dopaminergic deficit and response to L-dopa is largely unknown. We report a 43-year-old woman with a PSEN1 mutation (A434T) who showed right side dominant parkinsonism. As disease progressed, she developed bilateral parkinsonism which was markedly relieved by L-dopa. Amyloid (Florbetaben) positron-emission tomography (PET) showed cortical florbetaben uptake, relatively sparing the striatum. Initial dopamine transporter (FP-CIT) PET showed asymmetrically decreased FP-CIT uptake in the left striatum. We suggest that in Alzheimer's disease patients with PSEN1 mutation, parkinsonism may be relieved by L-dopa when it is associated with presynaptic dopaminergic deficit. | en_US |
dc.description.sponsorship | This research was supported by grants of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI18C03 35, HI18C1629, and HI14C2746); and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2018R1A1A3A0 4079255). | en_US |
dc.language.iso | en | en_US |
dc.publisher | IOS Press | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | FP-CIT PET | en_US |
dc.subject | L-dopa | en_US |
dc.subject | parkinsonism | en_US |
dc.subject | presenilin 1 | en_US |
dc.title | Dopa Responsive Parkinsonism in an Early Onset Alzheimer's Disease Patient with a Presenilin 1 Mutation (A434T) | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 71 | - |
dc.identifier.doi | 10.3233/JAD-190469 | - |
dc.relation.page | 7-13 | - |
dc.relation.journal | Journal of Alzheimer's Disease | - |
dc.contributor.googleauthor | Jo, Hyunjin | - |
dc.contributor.googleauthor | Kim, Minkyeong | - |
dc.contributor.googleauthor | Park, Seongbeom | - |
dc.contributor.googleauthor | Park, Jong Eun | - |
dc.contributor.googleauthor | Cho, Soo Hyun | - |
dc.contributor.googleauthor | Kim, Seung Joo | - |
dc.contributor.googleauthor | Jang, Hyemin | - |
dc.contributor.googleauthor | Jung, Yong Hee | - |
dc.contributor.googleauthor | Kim, Junpyo | - |
dc.contributor.googleauthor | Na, Duk L. | - |
dc.relation.code | 2019021030 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jongeun820 | - |
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