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A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA‐g‐OLA)s

Title
A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA‐g‐OLA)s
Author
임동우
Issue Date
2000-05
Publisher
Wiley
Citation
Macromolecular Rapid Communications, v. 21, no. 8, page. 464-471
Abstract
Communication: Two enantiomeric amphiphilic graft copolymers consisting of water soluble poly(2-hydro-xyethyl methacrylate) (HEMA) and biodegradable oligo(L-lactide) (OLLA) or oligo(D-lactide) (ODLA) were synthesized by free radical copolymerization. HEMA-OL(D)LA macromonomers were synthesized by ring opening polymerization of L- or D-lactide. Both HEMA-OLA macromonomers and graft copolymers were characterized by NMR spectroscopy and gel permeation chromatography. Graft copolymers and their stereocomplexes were analyzed by wide angle X-ray diffraction and differential scanning calorimetry (DSC). Due to the formation of stereocomplex crosslinks between poly(HEMA) main chains, amphiphilic, biodegradable hydrogels prepared by blending of two enantiomeric poly(HEMA-g-OLLA) and poly(HEMA-g-ODLA) degraded more slowly in phosphate buffered saline than individual optically purr poly(HEMA-g-OL(D)LA).
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1521-3927(20000501)21:8%3C464::AID-MARC464%3E3.0.CO;2-%23https://repository.hanyang.ac.kr/handle/20.500.11754/161700
ISSN
1022-1336
DOI
10.1002/(sici)1521-3927(20000501)21:8<464::aid-marc464>3.0.co;2-%23
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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