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Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review

Title
Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review
Author
최호순
Keywords
Sorafenib; Coronary artery vasospasm; Variant angina; Tyrosine kinase inhibitor; Vascular endothelial growth factor inhibitor
Issue Date
2020-02
Publisher
The Korean Liver Cancer Association
Citation
Journal of Liver Cancer, v. 20, no. 1, page. 67-71
Abstract
Tyrosine kinase inhibitors are widely used as targeted treatments for various malignancies. Sorafenib is an orally active tyrosine kinase inhibitor that blocks the signaling pathways of several growth factors. Its use is approved for various malignancies such as unresectable hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumors. Several adverse effects have been reported in the literature; however, cardiotoxicity is rare. We present a case of recurrent coronary vasospasm caused by short-term administration (5 days) of sorafenib. Since it caused refractory ischemia after re-administration, we had no choice but to stop the treatment.
URI
https://www.e-jlc.org/journal/view.php?doi=10.17998/jlc.20.1.67https://repository.hanyang.ac.kr/handle/20.500.11754/161412
ISSN
2288-8128; 2383-5001
DOI
10.17998/jlc.20.1.67
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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