Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2021-04-15T01:14:09Z | - |
dc.date.available | 2021-04-15T01:14:09Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | FRONTIERS IN IMMUNOLOGY, v. 11, article no. 68 | en_US |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://www.frontiersin.org/articles/10.3389/fimmu.2020.00068/full | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/161389 | - |
dc.description.abstract | Uncontrolled activation of transforming growth factor (TGF)-beta results in a wide range of pathologic conditions. Therapeutic interventions to regulate TGF-beta signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates fibrosis in mice by inhibiting alpha(v) integrin-mediated activation of TGF-beta. Del-1 bound to alpha(v)beta(6) integrin, an important activator of TGF-beta, and inhibited the binding of alpha(v)beta(6) integrin to the latency-associated peptide (LAP), thereby suppressing alpha(v) integrin-mediated activation of TGF-beta. Lack of Del-1 increased colocalization of alpha(v) integrin and LAP in the lungs, which was reversed by Del-1 supplementation. The crucial role of Del-1 in regulating TGF-beta activity was recapitulated in a mouse model of fibrosis using an adenovirus expressing inactive TGF-beta 1. Del-1 supplementation improved the pathological characteristics of the mice and reduced mortality. Thus, we propose that Del-1 is a negative regulator of TGF-beta activation and a potential anti-fibrotic factor. | en_US |
dc.description.sponsorship | This work was supported by a National Research Foundation grant funded by the Ministry of Science and ICT (MSIT) of the government of Korea (2016R1E1A1A01943329). | en_US |
dc.language.iso | en | en_US |
dc.publisher | FRONTIERS MEDIA SA | en_US |
dc.subject | Del-1 (developmental endothelial locus-1) | en_US |
dc.subject | integrins | en_US |
dc.subject | fibrosis | en_US |
dc.subject | transforming growth factor-beta activation | en_US |
dc.subject | inflammation | en_US |
dc.title | Del-1, an Endogenous Inhibitor of TGF-beta Activation, Attenuates Fibrosis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.3389/fimmu.2020.00068 | - |
dc.relation.page | 68-68 | - |
dc.relation.journal | FRONTIERS IN IMMUNOLOGY | - |
dc.contributor.googleauthor | Kim, Dong-Young | - |
dc.contributor.googleauthor | Lee, Seung-Hwan | - |
dc.contributor.googleauthor | Fu, Yan | - |
dc.contributor.googleauthor | Jing, Feifeng | - |
dc.contributor.googleauthor | Kim, Won-Young | - |
dc.contributor.googleauthor | Hong, Sang-Bum | - |
dc.contributor.googleauthor | Song, Jung-A | - |
dc.contributor.googleauthor | Choe, Han | - |
dc.contributor.googleauthor | Ryu, Hyun Jin | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.relation.code | 2020050760 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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