Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영주 | - |
dc.date.accessioned | 2021-04-12T07:10:06Z | - |
dc.date.available | 2021-04-12T07:10:06Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | JOURNAL OF CLINICAL NEUROSCIENCE, v. 73, Page. 215-218 | en_US |
dc.identifier.issn | 0967-5868 | - |
dc.identifier.issn | 1532-2653 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0967586819323501?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/161367 | - |
dc.description.abstract | Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P ˂ 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke. (C) 2020 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program of the National Research Foundation of Korea, which is funded by the Ministry of Science, ICT, and Future Planning (2018R1A2A2A15023219); by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C2160 and HI18C1254); research fund of Hanyang University (HY-2019); and by the Medical Research Center (2017R1A5A2015395). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | sTREM2 | en_US |
dc.subject | Microglia | en_US |
dc.subject | Ischemic stroke | en_US |
dc.subject | Prognosis | en_US |
dc.title | Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke | en_US |
dc.type | Article | en_US |
dc.relation.volume | 73 | - |
dc.identifier.doi | 10.1016/j.jocn.2020.02.016 | - |
dc.relation.page | 215-218 | - |
dc.relation.journal | JOURNAL OF CLINICAL NEUROSCIENCE | - |
dc.contributor.googleauthor | Kwon, Hyuk Sung | - |
dc.contributor.googleauthor | Lee, Eun-Hye | - |
dc.contributor.googleauthor | Park, Hyun-Hee | - |
dc.contributor.googleauthor | Jin, Jeong-Hwa | - |
dc.contributor.googleauthor | Choi, Hojin | - |
dc.contributor.googleauthor | Lee, Kyu-Yong | - |
dc.contributor.googleauthor | Lee, Young Joo | - |
dc.contributor.googleauthor | Lee, Jae-Hong | - |
dc.contributor.googleauthor | de Oliveira, Felipe Marques Souza | - |
dc.contributor.googleauthor | Kim, Hyun Young | - |
dc.relation.code | 2020051726 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yjlee1 | - |
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