82 0

Incidence of acute spinal cord injury and associated complications of methylprednisolone therapy: a national population-based study in South Korea

Title
Incidence of acute spinal cord injury and associated complications of methylprednisolone therapy: a national population-based study in South Korea
Author
강창남
Keywords
HIGH-DOSE METHYLPREDNISOLONE; SODIUM SUCCINATE; PREVALENCE; EPIDEMIOLOGY; RECOVERY; STEROIDS; NALOXONE
Issue Date
2020-02
Publisher
NATURE PUBLISHING GROUP
Citation
SPINAL CORD, v. 58, no. 2, page. 232-237
Abstract
Study design Retrospective population-based cohort study Objectives To evaluate the incidence of acute spinal cord injury (SCI) in South Korea, and the prescription rates and complications related to high dose methylprednisolone therapy. Setting Health Insurance Review and Assessment Service (HIRA) data Methods National database of the Korean HIRA between 2007 and 2017 was reviewed. To identify patients with acute SCI and the use of high dose methylprednisolone, International Classification of Disease revision codes, medical behavior codes and examination codes were used. Patients were grouped according to whether or not they received methylprednisolone therapy (MP group vs non-MP group). Results The average age-adjusted incidence of acute SCI per 1,000,000 persons was 26.4 and the peak incidence was in the 50s overall. The methylprednisolone prescription rate was highest in 2012 (76%) and continued to decrease thereafter, being lowest in 2017 (41%). The MP group showed higher complication rates in terms of pneumonia (OR 1.8, 95% CI, 1.62-2.0), GI bleeding (OR 1.2, 95% CI, 1.05-1.38), and UTI (OR 1.68, 95% CI, 1.53-1.84). The average length of hospitalization was longer in patients who received methylprednisolone (26.5 days vs. 24.4 days, p ˂ 0.05). Conclusions The average age-adjusted incidence of acute SCI for 11 years was 26.4 per 1,000,000 persons and highest in 50s. Strategies should be established, and national health resources should be allocated to prevent acute SCI from occurring in older people. The prescription rate of high dose methylprednisolone for acute SCI is decreasing in South Korea but it is still high.
URI
https://www.nature.com/articles/s41393-019-0357-2https://repository.hanyang.ac.kr/handle/20.500.11754/161308
ISSN
1362-4393; 1476-5624
DOI
10.1038/s41393-019-0357-2
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE