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Anterior cruciate ligament remnant cells have different potentials for cell differentiation based on their location

Title
Anterior cruciate ligament remnant cells have different potentials for cell differentiation based on their location
Author
이진규
Keywords
ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; TENSIONING TECHNIQUE; GROWTH-FACTOR; RECONSTRUCTION; GRAFT; 2ND-LOOK; RABBIT; TRANSPLANTATION; SYNOVIALIZATION
Issue Date
2020-02
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 10, no. 1, article no. 3097
Abstract
Histological and cytological observations of the human anterior cruciate ligament (ACL) had been described, but the differentiation potency based on their location is still unknown. To determine and compare proliferation and differentiation potential of cells derived from distal and middle thirds of the ACL remnant, ACL remnant was initially marked at the distal third (within 10 mm from the tibial insertion) and middle third (between 10-20 mm from the tibial insertion) and then dissected. Both the middle and distal third regions of ACL remnant were analyzed using CD34(+) cell counting. Cell proliferation rate did not differ in both middle and distal third regions of ACL remnant, but they showed different characteristics in cell differentiation depending on their location. The distal third region of the ACL remnant had a tendency for chondrogenic differentiation with higher expression of CD34(+) cells. On the other hand, the middle third region of ACL remnant had a strong tendency for osteogenic and ligamentous differentiation. Characteristics of the ACL remnant tissues should be considered when performing remnant-preserving or harvesting ACL remnants for tissue engineering.
URI
https://www.nature.com/articles/s41598-020-60047-whttps://repository.hanyang.ac.kr/handle/20.500.11754/161282
ISSN
2045-2322
DOI
10.1038/s41598-020-60047-w
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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