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Diagnostic Performance of Serum Asialo α1-Acid Glycoprotein Levels to Predict Liver Cirrhosis

Title
Diagnostic Performance of Serum Asialo α1-Acid Glycoprotein Levels to Predict Liver Cirrhosis
Author
김미미
Keywords
Asialo alpha 1-acid glycoprotein; Liver cirrhosis; Chronic hepatitis; Magnetic resonance elastography
Issue Date
2020-02
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v. 15, no. 1, page. 109-116
Abstract
Background/Aims: To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of serum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result. Methods: We conducted a casecontrol study of 96 patients with chronic liver disease. Chronic hepatitis was defined as the presence of chronic liver disease on ultrasonography, with a liver stiffness of less than 5.0 kPa as shown on magnetic resonance elastography (MRE). Liver cirrhosis was defined as liver stiffness of more than 5.0 kPa on MRE. The serum AsAGP concentration was compared between the two groups. Results: Serum AsAGP levels were significantly higher in patients with cirrhosis than in those with chronic hepatitis (1.83 μg/mL vs 1.42 μg/mL, p˂0.001). Additionally, when comparing patients in each cirrhotic group (Child-Pugh grades A, B, and C) to those with chronic hepatitis, AsAGP levels were significantly higher in all the cirrhotic groups (p˂0.05, p˂0.01, p˂0.001, respectively). The sensitivity and specificity of AsAGP for detecting cirrhosis were 79.2% and 64.6%, respectively, and the area under the curve value was 0.733. The best diagnostic cutoff to predict cirrhosis was 1.4 μg/mL. AsAGP and bilirubin were found to be independent risk factors for the prediction of cirrhosis in the logistic regression analysis. Conclusions: Serum AsAGP showed an acceptable diagnostic performance in predicting liver cirrhosis.
URI
http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl19282https://repository.hanyang.ac.kr/handle/20.500.11754/161277
ISSN
1976-2283; 2005-1212
DOI
10.5009/gnl19282
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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