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dc.contributor.author이준호-
dc.date.accessioned2021-03-25T04:32:31Z-
dc.date.available2021-03-25T04:32:31Z-
dc.date.issued2020-01-
dc.identifier.citationPATHOLOGY RESEARCH AND PRACTICE, v. 216, no. 3, article no. 152821en_US
dc.identifier.issn0344-0338-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0344033819321120?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/160862-
dc.description.abstractThis study aimed to investigate the clinicopathological and prognostic impact of B-cell linker (BLNK) protein expression in colorectal cancer (CRC) as its function in CRC remains unexplored. We performed immunohistochemical staining for BLNK using tissue microarrays of 418 consecutive CRC samples; of these 10 were excluded due to inappropriate staining. The expression intensity and staining level was scored as 0-3 and 0-4, respectively, based on the percentage of positive cells. The immunoreactivity score (IRS) was calculated by multiplying these two scores. BLNK expression was observed in 222 patients (54.4 %). Lymph node metastasis (p = 0.031), right colon cancer (p = 0.026), mutinous adenocarcinoma (p < 0.001), and perineural invasion (p = 0.049) were more frequently observed in the IRS 4-12 group than in the IRS 0-3 group. At the same cutoff point, the 5-year recurrence-free survival rate of the patients with stage HI was significantly lower than that observed in IRS 4-12 group (74.8 % +/- 4.2 % vs. 54.2 +/- 8.5 %, p = 0.003). Multivariate analysis revealed IRS 4-12 to be an independent risk factor for recurrence (Hazard ratio 2.346, 95 % confidence interval 1.348-4.085, p = 0.003). In conclusion, overexpression of BLNK protein is an independent risk factor for CRC recurrence.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2015).en_US
dc.language.isoenen_US
dc.publisherELSEVIER GMBHen_US
dc.subjectBLNKen_US
dc.subjectColorectalen_US
dc.subjectAdenocarcinomaen_US
dc.subjectLymph node metastasisen_US
dc.subjectPrognosisen_US
dc.titlePrognostic value of B-cell linker protein in colorectal canceren_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.prp.2020.152821-
dc.relation.journalPATHOLOGY RESEARCH AND PRACTICE-
dc.contributor.googleauthorLee, Jun Ho-
dc.contributor.googleauthorLee, Ju-Hee-
dc.contributor.googleauthorAhn, Byung Kyu-
dc.contributor.googleauthorPaik, Seung Sam-
dc.contributor.googleauthorLee, Kang Hong-
dc.relation.code2020046525-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidduno82-
dc.identifier.orcidhttp://orcid.org/0000-0001-9651-4222-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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