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Prognostic value of B-cell linker protein in colorectal cancer

Title
Prognostic value of B-cell linker protein in colorectal cancer
Author
이준호
Keywords
BLNK; Colorectal; Adenocarcinoma; Lymph node metastasis; Prognosis
Issue Date
2020-01
Publisher
ELSEVIER GMBH
Citation
PATHOLOGY RESEARCH AND PRACTICE, v. 216, no. 3, article no. 152821
Abstract
This study aimed to investigate the clinicopathological and prognostic impact of B-cell linker (BLNK) protein expression in colorectal cancer (CRC) as its function in CRC remains unexplored. We performed immunohistochemical staining for BLNK using tissue microarrays of 418 consecutive CRC samples; of these 10 were excluded due to inappropriate staining. The expression intensity and staining level was scored as 0-3 and 0-4, respectively, based on the percentage of positive cells. The immunoreactivity score (IRS) was calculated by multiplying these two scores. BLNK expression was observed in 222 patients (54.4 %). Lymph node metastasis (p = 0.031), right colon cancer (p = 0.026), mutinous adenocarcinoma (p < 0.001), and perineural invasion (p = 0.049) were more frequently observed in the IRS 4-12 group than in the IRS 0-3 group. At the same cutoff point, the 5-year recurrence-free survival rate of the patients with stage HI was significantly lower than that observed in IRS 4-12 group (74.8 % +/- 4.2 % vs. 54.2 +/- 8.5 %, p = 0.003). Multivariate analysis revealed IRS 4-12 to be an independent risk factor for recurrence (Hazard ratio 2.346, 95 % confidence interval 1.348-4.085, p = 0.003). In conclusion, overexpression of BLNK protein is an independent risk factor for CRC recurrence.
URI
https://www.sciencedirect.com/science/article/pii/S0344033819321120?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/160862
ISSN
0344-0338
DOI
10.1016/j.prp.2020.152821
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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