Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이학준 | - |
dc.date.accessioned | 2021-03-10T02:48:45Z | - |
dc.date.available | 2021-03-10T02:48:45Z | - |
dc.date.issued | 2001-12 | - |
dc.identifier.citation | ARCHIV DER PHARMAZIE, v. 334, issue. 11, page. 345-350 | en_US |
dc.identifier.issn | 0365-6233 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002%2F1521-4184%28200112%29334%3A11%3C345%3A%3AAID-ARDP345%3E3.0.CO%3B2-1? | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/160468 | - |
dc.description.abstract | In this study, C-2, C-8, N-9 substituted 6-(3-chloroanilino)purine derivatives were syn-thesized and their inhibitory effects on cyclin-dependent kinases (CDK2, 4) as well astheir cytotoxicities were evaluated. The effects of substituents at the C-2, C-8, and N-9positions of the substituted purine were investigated. Among the compounds tested,[6-(3-chloroanilino)-2-(2-hydroxymethyl-4-hydroxypyrrolidyl)-9-isopropylpurine] (4h)was the most active inhibitor of CDK2 with IC50 of 0.3µM, i.e. a two-fold increasedinhibitory activity as compared to roscovitine. Results from structure-activity relationshipstudies should allow the design of more potent and selective CDK2 inhibitors, which mayprovide an effective therapy for cancer or other CDK-dependent diseases. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | CDK2 inhibitor | en_US |
dc.subject | m-Chloroanilinopurine | en_US |
dc.subject | Cell cycle regulation | en_US |
dc.subject | Antiprolifera-tive effect | en_US |
dc.title | Synthesis and Biological Properties of C-2, C-8, N-9 Substituted 6-(3-Chloroanilino)-purine Derivatives as Cyclin-Dependent Kinase Inhibitors, Part 2 | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/1521-4184(200112)334:11<345::AID-ARDP345>3.0.CO;2-1 | - |
dc.relation.journal | ARCHIV DER PHARMAZIE | - |
dc.contributor.googleauthor | Oh, C.-H. | - |
dc.contributor.googleauthor | Lee, S.-C. | - |
dc.contributor.googleauthor | Yang, B.-S. | - |
dc.contributor.googleauthor | Cho, J.-H. | - |
dc.contributor.googleauthor | Kim, H.-K. | - |
dc.contributor.googleauthor | Oh, C. | - |
dc.contributor.googleauthor | Rhee, H.J. | - |
dc.relation.code | 2009200911 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | hrhee | - |
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