Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 황정욱 교수님 | - |
dc.contributor.author | 김민우 | - |
dc.date.accessioned | 2021-02-24T16:08:28Z | - |
dc.date.available | 2021-02-24T16:08:28Z | - |
dc.date.issued | 2021. 2 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/159087 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000485766 | en_US |
dc.description.abstract | It has been revealed that long non-coding RNAs (lncRNAs) play a critical role in hepatocellular carcinoma (HCC). The Long Non-Coding RNA High Expression In Hepatocellular Carcinoma (lncRNA-HEIH) facilitates tumor growth through interaction with enhancer of zeste homolog 2 (EZH2) in HCC. Although the functions of lncRNA-HEIH have been studied, the regulation mechanism of lncRNA-HEIH is not elucidated. RNA binding proteins (RBPs) are critical to the post-transcriptional regulation of RNA. One of the best-known RBPs is up-frameshift protein 1 (UPF1), a member of the superfamily 1 (SF1) RNA helicase. The different effects of UPF1 and lncRNA-HEIH in HCC have been identified, i.e., the overexpression of UPF1 and lncRNA-HEIH drives HCC growth in the opposite direction. Using transcriptome-wide analysis upon depletion of UPF1, we found that the expression of lncRNA-HEIH was regulated by UPF1, and the expression of lncRNA-HEIH was reversely correlated with the expression of UPF1. In addition, by analyzing public UPF1 cross-linking immunoprecipitation and sequencing (CLIP-seq), RNA immunoprecipitation (RIP), and mutagenesis experiments, we confirmed that UPF1 bound to lncRNA-HEIH. Our results suggest that UPF1 regulates the stability of lncRNA-HEIH by binding it. | - |
dc.publisher | 한양대학교 | - |
dc.title | The effects of UPF1 on lncRNA-HEIH stability in hepatocellular carcinoma | - |
dc.type | Theses | - |
dc.contributor.googleauthor | Min woo Kim | - |
dc.contributor.alternativeauthor | 김민우 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 의생명공학전문대학원 | - |
dc.sector.department | 의생명과학과 | - |
dc.description.degree | Master | - |
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