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dc.contributor.author최한곤-
dc.date.accessioned2021-02-16T05:48:29Z-
dc.date.available2021-02-16T05:48:29Z-
dc.date.issued2001-05-
dc.identifier.citationDrug Development and Industrial Pharmacy, v. 27, issue. 5, page. 447-455en_US
dc.identifier.issn0363-9045-
dc.identifier.issn1520-5762-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1081/DDC-100104320-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/158412-
dc.description.abstractThe objective of this study was to develop an effective omeprazole buccal adhesive tablet with excellent bioadhesive force and good drug stability in human saliva. The omeprazole buccal adhesive tablets were prepared with various bioadhesive polymers, alkali materials, and croscarmellose sodium. Their physicochemical properties, such as bioadhesive force and drug stability in human saliva, were investigated. The release and bioavailability of omeprazole delivered by the buccal adhesive tablets were studied. As bioadhesive additives for the omeprazole tablet, a mixture of sodium alginate and hydroxypropylmethylcellulose (HPMC) was selected. The omeprazole tablets prepared with bioadhesive polymers alone had bioadhesive forces suitable for a buccal adhesive tablet, but the stability of omeprazole in human saliva was not satisfactory. Among alkali materials, only magnesium oxide could be an alkali stabilizer for omeprazole buccal adhesive tablets due to its strong waterproofing effect. Croscarmellose sodium enhanced the release of omeprazole from the tablets; however, it decreased the bioadhesive forces and stability of omeprazole tablets in human saliva. The tablet composed of omeprazole/sodium alginate/HPMC/magnesium oxide/croscarmellose sodium (20/24/6/50/10 mg) could be attached on the human cheek without disintegration, and it enhanced the stability of omeprazole in human saliva for at least 4 h and gave fast release of omeprazole. The plasma concentration of omeprazole in hamsters increased to a maximum of 370 ng/ml at 45 min after buccal administration and continuously maintained a high level of 146–366 ng/ml until 6 h. The buccal bioavailability of omeprazole in hamsters was 13.7% ± 3.2%. These results demonstrate that the omeprazole buccal adhesive tablet would be useful for delivery of an omeprazole that degrades very rapidly in acidic aqueous medium and undergoes hepatic first-pass metabolism after oral administration.en_US
dc.description.sponsorshipThis work was supported by Korea Research Foundation grant KRF-2000-003-F00307.en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subjectBioadhesive forceen_US
dc.subjectBuccal adhesive tableten_US
dc.subjectDissolutionen_US
dc.subjectOmeprazoleen_US
dc.subjectPharmacokineticsen_US
dc.subjectStability in human salivaen_US
dc.titlePhysicochemical characterization and evaluation of buccal adhesive tablets containing omeprazoleen_US
dc.typeArticleen_US
dc.relation.volume27-
dc.identifier.doi10.1081/DDC-100104320-
dc.relation.page447-455-
dc.relation.journalDRUG DEVELOPMENT AND INDUSTRIAL PHARMACY-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorJung, Jae-Hee-
dc.contributor.googleauthorRhee, Jong-Dal-
dc.contributor.googleauthorKim, Chong-Kook-
dc.contributor.googleauthorChoi, Han-Gon-
dc.relation.code2009202645-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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