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다양한 비스테로이드성 소염진통제의 쥐 피부 투과

Title
다양한 비스테로이드성 소염진통제의 쥐 피부 투과
Other Titles
In vitro Rat Skin Permeation of Various NSAIDs
Author
최한곤
Keywords
NASID; Enhancer; Skin permeation
Issue Date
2002-12
Publisher
한국약제학회
Citation
약제학회지, v. 32, no. 4, page. 313-319
Abstract
Rat skin permeation of various nonsteroidal antiinflammatory drugs (NSAIDs) was investigated in vitro using Franz diffusion cell at 37℃. The effect of various skin permeation enhancers was also observed as a preliminary study of developing transdermal delivery systems of NSAIDs. Lipophilicity of NSAIDs was determined from the partition coefficient (log P) in 1-octanol/water and 1-octanol/IPB mutual-saturated solutions. The solubility was determined in water, isotonic phosphate buffer (IPB), and propylene glycol (PG) at 37℃. The rat skin permeation rate of acetaminophen, piroxicam, and aceclofenac was almost negligible, although they were saturated in PG. Addition of 1 % permeation enhancer increased the permeation rate of ketoprofen, ketorolac, and diclofenac. However, the skin permeation rate of ibuprofen did not increase with the addition of various enhancers. Among the permeation enhancers tested, oleic acid was the most effective for various NSAIDs. Based on the daily dose, lipophilicity, and the skin permeation rate achieved in this study, ketoprofen and ketorolac seem to be the most promising drug candidates for transdermal delivery systems, especially when formulated with unsaturated fatty acids, such as oleic acid.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=1983667https://repository.hanyang.ac.kr/handle/20.500.11754/157486
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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