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헬리코박터 파이로리 균 집당용 13C-요소 캅셀의 개발

Title
헬리코박터 파이로리 균 집당용 13C-요소 캅셀의 개발
Other Titles
Development of 13C - urea - containing capsule for diagnosis of H. pylori
Author
최한곤
Keywords
pylori urea; polyethylene glycol; dissolution test; 13C-urea breath test
Issue Date
2002-02
Publisher
한국약제학회
Citation
한국약제학회지, v. 32, no. 1, page. 7-11
Abstract
The purpose of this study was to develop a new ^13C-urea- containing capsule for diagnosis of H. pylori. The urea-containing capsules were prepared with various diluents such as polyethylene glycol (PEG), microcrystalline cellulose, sodium lauryl sulfate and citric acid. The dissolution test, ^13C-urea breath test and stability test were then performed on the capsules. Microcrystalline cellulose and sodium lauryl sulfate retarded the initial dissolution rates of urea. However, PEG increased the initial dissolution rates of urea. Furthermore, two formulae composed of PEG, [^13C-urea/PEG (38/1.9 mg/cap)] and [^13C-urea/PEG/citric acid (38/1.9/1.9 mg/cap)] had the maximum DOB value, about 16 at 20 mim, while the formula composed of only 38 mg ^13C-urea had the maximum DOB value at 30 min. The results indicated that PEG improved the sensitivity of ^13C-urea in the human volunteers. The capsule [^13C-urea/PEG (38/1.9 mg/cap)] was stable for at least six months in 25 and 37℃. Thus, a PEG-containing capsule, [^13C-urea/PEG (38/1.9 mg/cap)] would be a more economical, sensitive and stable preparation for diagnosis of H. pylori.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=1920347https://repository.hanyang.ac.kr/handle/20.500.11754/156820
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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