Applicability of laser-induced Raman microscopy for in situ monitoring of imine formation in a glass microfluidic chip
- Title
- Applicability of laser-induced Raman microscopy for in situ monitoring of imine formation in a glass microfluidic chip
- Author
- 채영규
- Keywords
- microfluidic chip; Raman microscopy; on-chip detection; in situ monitoring; imine formation
- Issue Date
- 2003-10
- Publisher
- JOHN WILEY & SONS LTD
- Citation
- JOURNAL OF RAMAN SPECTROSCOPY, v. 34, issue. 10, page. 737-742
- Abstract
- Laser‐induced Raman microscopy has been used to illustrate its applicability for the in situ monitoring of imine formation reaction in a glass microfluidic chip. In order to monitor the diffusion process in a micro channel, the Raman spectra were measured at various points along the channel with a constant flow rate of 2.7 µl min−1. Time‐dependent Raman spectra were also measured without flow in order to monitor the variation of Raman peaks to a complete conversion. The disappearance of the CO stretching peak at 1700 cm−1 of the reactant, benzaldehyde, and the appearance of the Raman peak for the product, an imine, at 1628 cm−1 were successfully monitored. In addition, the intensity increases of three phenyl stretching modes in the 1550–1630 cm−1 region were also observed. The increase in Raman intensity for this vibrational mode is caused by an effective π‐electron conjugation between two phenyl rings through the —CN—bridging group of the product. Laser‐induced Raman microscopy enables us to monitor in situ product formation and to obtain detailed structural information in a glass microfluidic chip.
- URI
- https://onlinelibrary.wiley.com/doi/abs/10.1002/jrs.1038https://repository.hanyang.ac.kr/handle/20.500.11754/156362
- ISSN
- 0377-0486
- DOI
- 10.1002/jrs.1038
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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