82 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이영한-
dc.date.accessioned2020-11-27T06:41:32Z-
dc.date.available2020-11-27T06:41:32Z-
dc.date.issued2003-07-
dc.identifier.citationOncogene, v. 22, issue. 30, page. 4679–4689en_US
dc.identifier.issn0950-9232-
dc.identifier.urihttps://www.nature.com/articles/1206624#citeas-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/156025-
dc.description.abstractBasic studies of oncogenesis have demonstrated that either the elevated production of particular oncogene proteins or the occurrence of qualitative abnormalities in oncogenes can contribute to neoplastic cellular transformation. The purpose of this study was to identify unique oncogenes that are differentially expressed in human cancers and characterize their functions in tumorigenesis. To discover new putative oncogenes, the differential display RT–PCR method was applied using normal cervical tissues, cervical cancer cell lines, cervical cancer tissues, and metastatic tissues. We identified a new human cervical cancer oncogene HCCR-2 that was overexpressed in various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix. Ectopic expression of HCCR-2 resulted in direct tumorigenic conversions of NIH/3T3 and Rat1 fibroblasts. Nude mice injected with NIH/3T3 cells stably transfected with HCCR-2 formed tumors in 4 weeks. The resultant tumors display characteristics of an epithelial carcinoma. In HCCR-2 transfected NCI-H460 cells and RKO cells, stabilization of the p53 tumor suppressor occurred without genetic mutation and correlated with functional impairment, as indicated by the defective induction of p53-induced p21WAF1, MDM2, and bax. These results indicate that HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor.en_US
dc.description.sponsorshipSupported by a Grant (HMP-99-B-02-0002) of the 1999,Good Health R&D Project, Ministry of Health & Welfare, ROK. We thank JY Jung and W Kim for critically reading the manuscript.en_US
dc.language.isoen_USen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectHCCR-2en_US
dc.subjectcervical canceren_US
dc.subjectp53en_US
dc.subjectoncogeneen_US
dc.titleIdentification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.en_US
dc.typeArticleen_US
dc.identifier.doi10.1038/sj.onc.1206624-
dc.relation.journalONCOGENE-
dc.contributor.googleauthorKo, Jesang-
dc.contributor.googleauthorLee, Young Han-
dc.contributor.googleauthorHwang, Seung Yong-
dc.contributor.googleauthorLee, Youn Soo-
dc.contributor.googleauthorShin, Seung Min-
dc.contributor.googleauthorHwang, Jae Hoon-
dc.contributor.googleauthorKim, Jin-
dc.contributor.googleauthorKim, Yong Wook-
dc.contributor.googleauthorJang, Sung-Wuk-
dc.contributor.googleauthorRyoo, Zae Young-
dc.contributor.googleauthorKim, In-Kyung-
dc.contributor.googleauthorNamkoong, Sung Eun-
dc.contributor.googleauthorKim, Jin Woo-
dc.relation.code2009207260-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE & TECHNOLOGY[E]-
dc.sector.departmentDIVISION OF MOLECULAR & LIFE SCIENCE-
dc.identifier.pidyounghan-
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE