Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell
- Title
- Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell
- Author
- 이영식
- Keywords
- Nurr1; Dopaminergic neurogenesis; Tyrosine hydroxylase; Sonic hedgehog; FGF8; Human fetal astrocyte; Parkinson’s disease
- Issue Date
- 2003-06
- Publisher
- ACADEMIC PRESS INC
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 305, issue. 3, page. 1040-1048
- Abstract
- Neural stem cells are self-renewing cells capable of differentiating into all neural lineage cells in vivo and in vitro. In the present study, coordinated induction of midbrain dopaminergic phenotypes in an immortalized multipotent neural stem cell line can be achieved by both overexpression of nuclear receptor Nurr1, and fibroblast growth factor-8 (FGF-8), and sonic hedgehog (Shh) signals. Nurr1 overexpression induces neuronal differentiation and confers competence to respond to extrinsic signals such as Shh and FGF-8 that induce dopaminergic fate in a mouse neural stem cell line. Our findings suggest that immortalized NSCs can serve as an excellent model for understanding mechanisms that regulate specification of ventral midbrain DA neurons and as an unlimited source of DA progenitors for treating Parkinson disease patients by cell replacement.
- URI
- https://www.sciencedirect.com/science/article/pii/S0006291X03008799https://repository.hanyang.ac.kr/handle/20.500.11754/155925
- ISSN
- 0006-291X
- DOI
- 10.1016/S0006-291X(03)00879-9
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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