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dc.contributor.author최한곤-
dc.date.accessioned2020-11-24T05:40:26Z-
dc.date.available2020-11-24T05:40:26Z-
dc.date.issued2003-06-
dc.identifier.citation한국약제학회지, v. 33, no. 3, page. 171-178en_US
dc.identifier.issn2093-5552-
dc.identifier.urihttp://kiss.kstudy.com/thesis/thesis-view.asp?key=2099734-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/155846-
dc.description.abstractDrug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.en_US
dc.language.isoko_KRen_US
dc.publisher한국약제학회en_US
dc.subjectMetforminen_US
dc.subjectLaminaria japonicaen_US
dc.subjectDiabetesen_US
dc.subjectPharmacokineticsen_US
dc.title흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향en_US
dc.title.alternative흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향en_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume33-
dc.relation.page3-178-
dc.relation.journal한국약제학회지-
dc.contributor.googleauthor최한곤-
dc.contributor.googleauthor장보현-
dc.contributor.googleauthor이종달-
dc.contributor.googleauthor김정애-
dc.contributor.googleauthor유봉규-
dc.contributor.googleauthor용철순-
dc.relation.code2012101586-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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