Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영한 | - |
dc.date.accessioned | 2020-11-16T05:55:28Z | - |
dc.date.available | 2020-11-16T05:55:28Z | - |
dc.date.issued | 2003-04 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOLOGY, v. 23, issue. 9, page. 3103-3115 | en_US |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.uri | https://mcb.asm.org/content/23/9/3103 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/155589 | - |
dc.description.abstract | Phospholipase D (PLD) has been implicated in the signal transduction pathways initiated by several mitogenic protein tyrosine kinases. We demonstrate for the first time that most notably PLD2 and to a lesser extent the PLD1 isoform are tyrosine phosphorylated by c-Src tyrosine kinase via direct association. Moreover, epidermal growth factor induced tyrosine phosphorylation of PLD2 and its interaction with c-Src in A431 cells. Interaction between these proteins is via the pleckstrin homology domain of PLD2 and the catalytic domain of c-Src. Coexpression of PLD1 or PLD2 with c-Src synergistically enhances cellular proliferation compared with expression of either molecule. While PLD activity as a lipid-hydrolyzing enzyme is not affected by c-Src, wildtype PLDs but not catalytically inactive PLD mutants significantly increase c-Src kinase activity, up-regulating c-Src-mediated paxillin phosphorylation and extracellular signal-regulated kinase activity. These results demonstrate the critical role of PLD catalytic activity in the stimulation of Src signaling. In conclusion, we provide the first evidence that c-Src acts as a kinase of PLD and PLD acts as an activator of c-Src. This transmodulation between c-Src and PLD may contribute to the promotion of cellular proliferation via amplification of mitogenic signaling pathways. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | AMER SOC MICROBIOLOGY | en_US |
dc.title | Transmodulation between Phospholipase D and c-Src Enhances Cell Proliferation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1128/MCB.23.9.3103-3115.2003 | - |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.contributor.googleauthor | Ahn, Bong-Hyun | - |
dc.contributor.googleauthor | Kim, Shi Yeon | - |
dc.contributor.googleauthor | Kim, Eun Hee | - |
dc.contributor.googleauthor | Choi, Kyeong Sook | - |
dc.contributor.googleauthor | Kwon, Taeg Kyu | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.contributor.googleauthor | Chang, Jong-Soo | - |
dc.contributor.googleauthor | Kim, Myung-Suk | - |
dc.contributor.googleauthor | Jo, Yang-Hyeok | - |
dc.contributor.googleauthor | Min, Do Sik | - |
dc.relation.code | 2007206798 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE & TECHNOLOGY[E] | - |
dc.sector.department | DIVISION OF MOLECULAR & LIFE SCIENCE | - |
dc.identifier.pid | younghan | - |
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