Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조항준 | - |
dc.date.accessioned | 2020-11-11T01:11:27Z | - |
dc.date.available | 2020-11-11T01:11:27Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | BRAIN AND BEHAVIOR, v. 9, no. 12, article no. e01431 | en_US |
dc.identifier.issn | 2162-3279 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1431 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/155355 | - |
dc.description.abstract | Introduction While the clinical efficacy of deep brain stimulation (DBS) the treatment of motor-related symptoms is well established, the mechanism of action of the resulting cognitive and behavioral effects has been elusive. Methods By combining functional magnetic resonance imaging (fMRI) and DBS, we investigated the pattern of blood-oxygenation-level-dependent (BOLD) signal changes induced by stimulating the nucleus accumbens in a large animal model. Results We found that diffused BOLD activation across multiple functional networks, including the prefrontal, limbic, and thalamic regions during the stimulation, resulted in a significant change in inter-regional functional connectivity. More importantly, the magnitude of the modulation was closely related to the strength of the inter-regional resting-state functional connectivity. Conclusions Nucleus accumbens stimulation affects the functional activity in networks that underlie cognition and behavior. Our study provides an insight into the nature of the functional connectivity, which mediates activation effect via brain networks. | en_US |
dc.description.sponsorship | Hanyang University, Grant/Award Number: HY-2019; National Institutes of Health, Grant/Award Number: NIH C06 RR018898 and NIH R01 NS70872; The Grainger Foundation | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY | en_US |
dc.subject | blood-oxygenation-level-dependent hemodynamic response | en_US |
dc.subject | deep brain stimulation | en_US |
dc.subject | functional connectivity change | en_US |
dc.subject | functional magnetic resonance imaging | en_US |
dc.subject | network effect | en_US |
dc.subject | nucleus accumbens | en_US |
dc.subject | resting-state functional connectivity | en_US |
dc.title | Resting-state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1002/brb3.1431 | - |
dc.relation.page | 1431-1431 | - |
dc.relation.journal | BRAIN AND BEHAVIOR | - |
dc.contributor.googleauthor | Cho, Shinho | - |
dc.contributor.googleauthor | Hachmann, Jan T. | - |
dc.contributor.googleauthor | Balzekas, Irena | - |
dc.contributor.googleauthor | In, Myung-Ho | - |
dc.contributor.googleauthor | Andres-Beck, Lindsey G. | - |
dc.contributor.googleauthor | Lee, Kendall H. | - |
dc.contributor.googleauthor | Min, Hoon-Ki | - |
dc.contributor.googleauthor | Jo, Hang Joon | - |
dc.relation.code | 2019041840 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hangjoonjo | - |
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