Association between cerebral atrophy and osteoporotic vertebral compression fractures
- Title
- Association between cerebral atrophy and osteoporotic vertebral compression fractures
- Author
- 류제일
- Keywords
- VENTRICULAR ENLARGEMENT; ALZHEIMERS-DISEASE; BONE-FORMATION; RISK-FACTORS; WOMEN; FALLS; MEN
- Issue Date
- 2019-11
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v. 14, no. 11, article no. e0224439
- Abstract
- Purpose
Osteoporotic vertebral compression fractures (OVCFs) have a serious impact on people's health and quality of life. The purpose of this study was to analyze brain volume in patients with osteoporosis using brain magnetic resonance imaging (MRI) and to investigate the relationship with osteoporotic vertebral compression fractures.
Materials and methods
We included 246 patients with osteoporosis who underwent thoracolumbar radiographs and brain MRI at our hospital. Clinical data on age, sex, bone mineral density, height, weight, osteoporosis medication, hypertension, diabetes, alcohol drinking, and smoking were collected. Intracranial cavity, brain parenchyma, and lateral ventricles volumes were measured using brain MRI with a semiautomated tool.
Results
We founded an independent correlation between age and volume percentages of the brain parenchyma and lateral ventricles. We observed a statistically significant decrease in volume percentage of the brain parenchyma and an increase in volume percentage of the lateral ventricles with increasing age. In addition, we confirmed that patients with OVCF showed a significantly lower volume percentage of brain parenchyma than patients without OVCF.
Conclusion
We observed a significant association between OVCF and volume percentage of brain parenchyma. Degeneration of the brain may lead to a high incidence of falls, and OVCF may occur more frequently in patients with osteoporosis.
- URI
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224439https://repository.hanyang.ac.kr/handle/20.500.11754/155272
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0224439
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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