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dc.contributor.author최재훈-
dc.date.accessioned2020-11-09T05:16:49Z-
dc.date.available2020-11-09T05:16:49Z-
dc.date.issued2019-11-
dc.identifier.citationLaboratory Animal Research, v. 35, no. 4, Page. 148-153en_US
dc.identifier.issn2233-7660-
dc.identifier.issn1738-6055-
dc.identifier.urihttps://labanimres.biomedcentral.com/articles/10.1186/s42826-019-0021-1-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/155252-
dc.description.abstractPulmonary hypertension (PH) is a pathological state with sustained elevation of pulmonary artery (PA) pressure. Since the pathogenesis of PH is mostly irreversible, the disease often comes up with poor prognosis. Pulmonary arterioles are affected by deteriorative changes, such as development of occlusive lesions of thickening of arterial walls. Such processes increase the pulmonary arterial pressure thus lead to consequent injuries such as right ventricle failure. Proliferation, or resistance to apoptosis of pulmonary artery smooth muscle cells (PASMC) and fibroblasts, are characteristic changes observed in the PA in pulmonary arterial hypertension (PAH) patients. PAH can either occur idiopathically or come with other diseases. Emerging evidences suggest that pro-inflammatory processes are closely related to the development of PAH. Therefore, it is inferred that immune cells could be the key factors in PAH development. In this review, we summarize the way how each types of immune cells participate in PAH. We would also like to list the current rodent models used for PAH study.en_US
dc.description.sponsorshipThis research was supported by the National Research Foundation of Korea (NRF-2016M3A9D5A01952413).en_US
dc.language.isoenen_US
dc.publisher한국실험동물학회en_US
dc.subjectPulmonary hypertensionen_US
dc.subjectImmune cellsen_US
dc.subjectInflammationen_US
dc.subjectRodent modelsen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.titleInvolvement of immune responses in pulmonary arterial hypertension; lessons from rodent modelsen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume35-
dc.identifier.doi10.1186/s42826-019-0021-1-
dc.relation.page148-153-
dc.relation.journalLaboratory Animal Research-
dc.contributor.googleauthorKim, Kibyeong-
dc.contributor.googleauthorChoi, Jae-Hoon-
dc.relation.code2019035315-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjchoi75-
dc.identifier.researcherIDR-6224-2016-
dc.identifier.orcidhttps://orcid.org/0000-0002-5265-3463-


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