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Involvement of immune responses in pulmonary arterial hypertension; lessons from rodent models

Title
Involvement of immune responses in pulmonary arterial hypertension; lessons from rodent models
Author
최재훈
Keywords
Pulmonary hypertension; Immune cells; Inflammation; Rodent models; Pulmonary arterial hypertension
Issue Date
2019-11
Publisher
한국실험동물학회
Citation
Laboratory Animal Research, v. 35, no. 4, Page. 148-153
Abstract
Pulmonary hypertension (PH) is a pathological state with sustained elevation of pulmonary artery (PA) pressure. Since the pathogenesis of PH is mostly irreversible, the disease often comes up with poor prognosis. Pulmonary arterioles are affected by deteriorative changes, such as development of occlusive lesions of thickening of arterial walls. Such processes increase the pulmonary arterial pressure thus lead to consequent injuries such as right ventricle failure. Proliferation, or resistance to apoptosis of pulmonary artery smooth muscle cells (PASMC) and fibroblasts, are characteristic changes observed in the PA in pulmonary arterial hypertension (PAH) patients. PAH can either occur idiopathically or come with other diseases. Emerging evidences suggest that pro-inflammatory processes are closely related to the development of PAH. Therefore, it is inferred that immune cells could be the key factors in PAH development. In this review, we summarize the way how each types of immune cells participate in PAH. We would also like to list the current rodent models used for PAH study.
URI
https://labanimres.biomedcentral.com/articles/10.1186/s42826-019-0021-1https://repository.hanyang.ac.kr/handle/20.500.11754/155252
ISSN
2233-7660; 1738-6055
DOI
10.1186/s42826-019-0021-1
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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