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폴록사머 188 및 멘톨에 의한 이부프로펜의 용해도 증가

Title
폴록사머 188 및 멘톨에 의한 이부프로펜의 용해도 증가
Other Titles
Enhanced Solubility of Ibuprofen with Poloxamer 188 and Menthol
Author
최한곤
Keywords
Ibuprofen; Menthol; Poloxamer 188; Solubility
Issue Date
2003-02
Publisher
한국약제학회
Citation
한국약제학회지, v.33, No.1, Page.57-60
Abstract
To enhance the solubility of poorly water-soluble ibuprofen with poloxamer and menthol, the effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigate. In the absence and presence of additives such as ethanol and poloxamer 188, the solubility of ibuprofen increased until the ratio of menthol to ibuprofen increased from 0:10 to 4:6 followed by and abrupt decrease in solubility above the ratio of 4:6, indicating tat 4 parts of ibuprofen formed eutetic mixture with 6 parts of menthol. In the presence of poloxamer, the solutions with the same ratio showed abrupt increase in the solubility of ibuprofen . Furthermore, in the presence of poloxamer, the solution with ratio of 4:6 showed more than 2.5- and 6-fold increase in the solubility of ibuprofen compared with that without additives and that without menthol, respectively. The solution with menthol/ibuprofen ratio of 1:9 and higher than 15% poloxamer 188 showed the maximum solubility of ibuprofen, 1.2㎎/ml. Thus, menthol gave the greatly enhanced solubility of ibuprofen with poloxamer 188.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2014026https://repository.hanyang.ac.kr/handle/20.500.11754/155035
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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