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클렌부테롤의 피부투과에 미치는 경피흡수촉진제의 영향

Title
클렌부테롤의 피부투과에 미치는 경피흡수촉진제의 영향
Other Titles
The Effect of Enhancers on the Penetration of Clenbuterol through Hairless Mouse Skin
Author
최한곤
Keywords
Clenbuterol; Enhancer; Transdermal drug delivery systems; Permeability
Issue Date
2003-03
Publisher
한국약제학회
Citation
한국약제학회지, v.33, No.1, Page. 5-36
Abstract
Clenbuterol, a selective β_2-adrenergic receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease, chronic bronchitis and pulmonary emphysema. The percutaneous permeation of clenbuterol was investigate in hairless mouse skin after application of 50/50 buffer(pH 10)/propylene glycol solvent mixture. The enhancing effects of various penetration enhancers such as terpenes, non-ionic surfactants, pyrrolidones, fatty acids and some other enhancers on the permeation of clenbuterol were evaluated using Franz diffusion cell. Among terpenes studied, 1,8-cineole was the most effective enhancer, which increase the permeability of clenbuterol approximately 39.33-fold compared with the control without penetration enhancer, followed by menthone with enhancement ratio of 23.57. Nonionic surfactants did not have significant enhancing effects. N-Lauryl-2-pyrrolidone increased the permeability of clenbuterol approximately 4.51-fold compared with the control. Lauric acid increased the permeability of clenbuterol approximately 35.57-fold with decreasing the lag time from 2.64 to 0.52 hr. Oleic acid, linoleic acid, the permeability of clenbuterol 9.24-fold compared with that without enhancer.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2014022https://repository.hanyang.ac.kr/handle/20.500.11754/155034
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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