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Solution state structure of pB1, the mimotopic peptide of apolipoprotein B-100, by NMR

Title
Solution state structure of pB1, the mimotopic peptide of apolipoprotein B-100, by NMR
Author
원호식
Keywords
Apolipoprotein B-100; NMR spectroscopy; Molecular dynamic computation
Issue Date
2004-12
Publisher
KOREAN CHEMICAL SOC(대한화학회)
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY(대한화학회), v.25, No.12, Page.1845-1849
Abstract
Apolipoprotein B-100 (Apo-B100) is a major protein component for low density lipoproteins (LDL). A number of mimetic peptides of Apo-B100 were screened from the phase-displayed random peptide library by utilizing monoclonal antibody (B9). Mimetic peptide for B9 epitope against apo B-100 was CRNVPPIFNDVYWIAF (pB1). From the BLAST search, the mimetic peptide pB1 had 40 % homology with apo B-100. As a result of the structural determination of this mimotope using homo/hetero nuclear 2D-NMR techniques and NMR-based distance geometry (DG) / molecular dynamic (MD) computations, DG structure had low penalty value of 0.3~0.6 Å2 and the total RMSD was 0.5~1.5 Å.
URI
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART000942293https://repository.hanyang.ac.kr/handle/20.500.11754/154762
ISSN
0253-2964
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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