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Investigation of Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure in Living Kidney Donors After Donor Nephrectomy

Title
Investigation of Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure in Living Kidney Donors After Donor Nephrectomy
Author
윤영은
Keywords
LONG-TERM CONSEQUENCES; ARTERIAL STIFFNESS; CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; RISK-FACTOR; FOLLOW-UP; DONATION
Issue Date
2019-10
Publisher
ELSEVIER SCIENCE INC
Citation
TRANSPLANTATION PROCEEDINGS, v. 51, no. 8, Page. 2533-2538
Abstract
Kidney transplants from living donors have increased, but few studies have examined the long-term risks of live donor nephrectomy. This is the first study to report the blood pressure (BP) changes associated with cardiovascular disease and linked to chronic kidney disease (CKD) 1 year after live donor nephrectomy. This study examined a prospective cohort of patients who underwent donor nephrectomy between March 1, 2006, and December 31, 2016, at the Severance Hospital, Seoul, South Korea. CKD was defined as a glomerular filtration rate (GFR) of < 60 mL/min/1.73m(2). Patients with a history of hypertension or CKD or an estimated GFR < 60 mL/min/1.73m(2) were excluded; those examined after 1 year post-nephrectomy were included in the study population. Among 420 patients who underwent donor nephrectomy, 137 (32.6%) developed a first-time onset of a GFR < 60 mL/min/1.73m(2) by the first year after surgery. After propensity score-matching the age, systolic BP (P < .001) and pulse pressure (P = .006) were significantly associated with the groups with newly developed CKD. Systolic BP and pulse pressure decreased significantly at 1 year after donor nephrectomy. These differences decreased after donor nephrectomy, possibly lowering the risk of cardiovascular disease.
URI
https://www.sciencedirect.com/science/article/pii/S004113451930257X?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/154699
ISSN
0041-1345; 1873-2623
DOI
10.1016/j.transproceed.2019.03.064
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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