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Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

Title
Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment
Author
윤채옥
Keywords
SUSTAINED DELIVERY; BLOCK-COPOLYMER; ALGINATE GEL; TEMPERATURE; VIROTHERAPY; BIODEGRADATION; MECHANISM; VECTORS; VIRUSES; MATRIX
Issue Date
2019-10
Publisher
ROYAL SOC CHEMISTRY
Citation
BIOMATERIALS SCIENCE, v. 7, no. 10, Page. 4195-4207
Abstract
A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads). Three different types of physically crosslinked hydrogels with different chemical compositions and properties were prepared. These hydrogels with good biocompatibility can be injected at pH 9.0 and room temperature and rapidly form a gel under body or tumor microenvironment conditions. Ads encapsulated in hydrogels were released gradually without burst release. Moreover, these physically crosslinked hydrogels provided a protective environment for Ads and maintained their bioactivity for a long period of time. Compared to naked Ads, Ads protected by these physically crosslinked hydrogels showed strong cytotoxicity to cancer cells even after 11 days. The Ad-loaded hydrogel system also exhibited enhanced and long-term antitumor therapeutic effects in human xenograft tumor models. Due to these outstanding properties, Ad-loaded injectable hydrogels might have potential for long-term cancer treatment.
URI
https://pubs.rsc.org/en/content/articlelanding/2019/BM/C9BM00992B#!divAbstracthttps://repository.hanyang.ac.kr/handle/20.500.11754/154685
ISSN
2047-4830; 2047-4849
DOI
10.1039/c9bm00992b
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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