Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박병배 | - |
dc.date.accessioned | 2020-10-13T02:25:14Z | - |
dc.date.available | 2020-10-13T02:25:14Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, no. 20, article no. 5010 | en_US |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://www.mdpi.com/1422-0067/20/20/5010 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/154552 | - |
dc.description.abstract | Chimeric antigen receptor (CAR) T-cell therapy has shown promising clinical impact against hematologic malignancies. CD19 is a marker on the surface of normal B cells as well as most B-cell malignancies, and thus has a role as an effective target for CAR T-cell therapy. In numerous clinical data, successes with cell therapy have provided anticancer therapy as a potential therapeutic option for patients who are resistant to standard chemotherapies. However, recent growing evidence showed the limitations of the treatment such as antigen-positive relapse due to poor CAR T-cell persistence and antigen-negative relapses associated with CAR-driven mutations, alternative splicing, epitope masking, low antigen density, and lineage switching. The understanding of the resistance mechanisms to the cell therapy has developed novel potential treatment strategies, including dual-targeting therapy (dual and tandem CAR), and armored and universal CAR T-cell therapies. In this review, we provide an overview of resistance mechanisms to CD19 CAR T-cell therapy in B-cell malignancies and also review therapeutic strategies to overcome these resistances. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | CAR T-cell | en_US |
dc.subject | drug resistance | en_US |
dc.subject | B cell hematologic malignancies | en_US |
dc.title | Resistance Mechanisms to CAR T-Cell Therapy and Overcoming Strategy in B-Cell Hematologic Malignancies | en_US |
dc.type | Article | en_US |
dc.relation.no | 20 | - |
dc.relation.volume | 20 | - |
dc.identifier.doi | 10.3390/ijms20205010 | - |
dc.relation.page | 1-17 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.contributor.googleauthor | Song, Moo-Kon | - |
dc.contributor.googleauthor | Park, Byeong-Bae | - |
dc.contributor.googleauthor | Uhm, Ji-Eun | - |
dc.relation.code | 2019041550 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | bbpark | - |
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