Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박종호 | - |
dc.date.accessioned | 2020-10-12T00:17:50Z | - |
dc.date.available | 2020-10-12T00:17:50Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | JOURNAL OF CLINICAL NEUROLOGY, v. 15, no. 4, Page. 545-554 | en_US |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.issn | 2005-5013 | - |
dc.identifier.uri | https://www.thejcn.com/DOIx.php?id=10.3988/jcn.2019.15.4.545 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/154499 | - |
dc.description.abstract | Background and Purpose The clinical implications of echocardiography findings for long-term outcomes in atrial fibrillation (AF)-related stroke patients are unknown. Methods This was a substudy of the Korean ATrial fibrillaTion EvaluatioN regisTry in Ischemic strOke patieNts (K-ATTENTION), which is a multicenter-based cohort comprising prospective stroke registries from 11 tertiary centers. Stroke survivors who underwent two-dimensional transthoracic echocardiography during hospitalization were enrolled. Echocardiography markers included the left-ventricle (LV) ejection fraction (LVEF), the left atrium diameter, and the ratio of the peak transmitral filling velocity to the mean mitral annular velocity during early diastole (E/e' ratio). LVEF was categorized into normal (>= 55%), mildly decreased (>40% and <55%), and severely decreased (<= 40%). The E/e' ratio associated with the LV filling pressure was categorized into normal (<8), borderline (>= 8 and <15), and elevated (>= 15). Kaplan-Meier and Cox regression analyses were performed for recurrent stroke, major adverse cardiac events, and all-cause death. Results This study finally included 1,947 patients. Over a median follow-up of 1.65 years (interquartile range, 0.42-2.87 years), the rates of recurrent stroke, major adverse cardiac events, and all-cause death were 35.1, 10.8, and 69.6 cases per 1,000 person-years, respectively. Multivariable analyses demonstrated that severely decreased LVEF was associated with a higher risks of major adverse cardiac events [hazard ratio (HR), 3.91; 95% confidence interval (CI), 1.58-9.69] and all-cause death (HR, 1.95; 95% CI, 1.23-3.10). The multivariable fractional polynomial plot indicated that recurrent stroke might be associated with a lower LVEF. Conclusions Severe LV systolic dysfunction could be a determinant of long-term outcomes in AF-related stroke. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Neurological Association (KNA-17-MI-10). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | en_US |
dc.subject | atrial fibrillation | en_US |
dc.subject | stroke | en_US |
dc.subject | echocardiography | en_US |
dc.subject | outcomes | en_US |
dc.title | Long-Term Outcomes of Real-World Korean Patients with Atrial-Fibrillation-Related Stroke and Severely Decreased Ejection Fraction | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3988/jcn.2019.15.4.545 | - |
dc.relation.page | 545-554 | - |
dc.relation.journal | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.contributor.googleauthor | Jung, Jin-Man | - |
dc.contributor.googleauthor | Kim, Yong-Hyun | - |
dc.contributor.googleauthor | Yu, Sungwook | - |
dc.contributor.googleauthor | O, Kyungmi | - |
dc.contributor.googleauthor | Kim, Chi Kyung | - |
dc.contributor.googleauthor | Song, Tae-Jin | - |
dc.contributor.googleauthor | Kim, Yong-Jae | - |
dc.contributor.googleauthor | Kim, Bum Joon | - |
dc.contributor.googleauthor | Heo, Sung Hyuk | - |
dc.contributor.googleauthor | Park, Jong-Ho | - |
dc.relation.code | 2019036969 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jhpark619 | - |
dc.identifier.orcid | https://orcid.org/0000-0002-2681-1878 | - |
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