52 0

콜로이드 골드 나노입자의 단백질 수송성 평가법

Title
콜로이드 골드 나노입자의 단백질 수송성 평가법
Other Titles
Protein-Coating Evaluation Method of Colloidal Gold Nanoparticles
Author
최한곤
Keywords
Colloidal gold nanoparticles; Protein delivery systems; Protein coating; Color testing method
Issue Date
2004-12
Publisher
한국약제학회
Citation
한국약제학회지, v. 34, No.6, Page. 465-469
Abstract
Colloidal gold nanoparticles might be of use as nano scale delivery systems of various therapeutic materials in the future. Recent studies have reported the feasibility of colloidal gold nanoparticles as gene delivery systems or protein delivery systems. In this study, we aimed to develop a short-step method useful for screening the optimal coating conditions of colloidal gold nanoparticles with proteins. We observed that colloidal gold nanoparticles have properties of changing its unique color when they were exposed to NaCl solution. Taking advantage of the color changing properties of colloidal gold nanoparticles, we applied the color testing method of colloidal gold nanoparticles solutions for evaluating the protein coating nature. Using bovine serum albumin as a model protein, we tested the protein coating of colloidal gold nanoparticles via the color change upon NaCl addition. The optimal coating concentration and coating conditions of colloidal gold nanoparticles with bovine serum albumin were fixed using the color testing methods. We suggest that the color testing method might be applied to optimize the coating condition of colloidal gold nanoparticles with other therapeutic proteins.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2396977https://repository.hanyang.ac.kr/handle/20.500.11754/154229
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE