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dc.contributor.author박동원-
dc.date.accessioned2020-09-16T02:22:02Z-
dc.date.available2020-09-16T02:22:02Z-
dc.date.issued2019-11-
dc.identifier.citationEUROPEAN RESPIRATORY JOURNAL, v. 54, no. 5, article no. 1900804en_US
dc.identifier.issn0903-1936-
dc.identifier.issn1399-3003-
dc.identifier.urihttps://erj.ersjournals.com/content/54/5/1900804-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/153957-
dc.description.abstractIntroduction: Chronic systemic corticosteroid (CS) therapy is associated with an increased risk of mortality in patients with many chronic diseases. However, it has not been elucidated whether chronic systemic CS therapy is associated with increased mortality in patients with asthma. The aim of this study was to determine the effects of chronic systemic CS therapy on long-term mortality in adult patients with asthma. Methods: A population-based matched cohort study of males and females aged >= 18 years with asthma was performed using the Korean National Health Insurance Service database from 2005 to 2015. Hazard ratio (HR) with 95% confidence interval for all-cause mortality among patients in the CS-dependent cohort (CS use >= 6 months during baseline period) relative to those in the CS-independent cohort (CS use <6 months during baseline period) was evaluated. Results: The baseline cohort included 466 941 patients with asthma, of whom 8334 were CS-dependent and 458 607 were CS-independent. After 1:1 matching, 8334 subjects with CS-independent asthma were identified. The HR of mortality associated with CS-dependent asthma relative to CS-independent asthma was 2.17 (95% CI 2.04-2.31). In patients receiving low-dose CS, the HR was 1.84 (95% CI 1.69-2.00); in patients receiving high-dose CS, the HR was 2.56 (95% CI 2.35-2.80). Conclusions: In this real-world, clinical practice, observational study, chronic use of systemic CS was associated with increased risk of mortality in patients with asthma, with a significant dose-response relationship between systemic CS use and long-term mortality.en_US
dc.description.sponsorshipThis study was funded by the Korea Ministry of Environment (MOE) as the Environmental Health Action Program (2016001360003) and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Korea (HI19C0218). The Korea MOE and KHIDI played no role in the design of the study, analysis and interpretation of data, and writing the current manuscript. Funding information for this article has been deposited with the Crossref Funder Registry.en_US
dc.language.isoenen_US
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTDen_US
dc.subjectREFRACTORY ASTHMAen_US
dc.subjectHEALTH-CAREen_US
dc.subjectDISEASEen_US
dc.subjectCOMPLICATIONSen_US
dc.subjectPREVALENCEen_US
dc.subjectMANAGEMENTen_US
dc.subjectBURDENen_US
dc.subjectRISKen_US
dc.subjectUKen_US
dc.titleIncreased Mortality in Patients with Corticosteroid-dependent Asthma: A Nationwide Population-based Studyen_US
dc.typeArticleen_US
dc.relation.volume1-
dc.identifier.doi10.1183/13993003.00804-2019-
dc.relation.page1-8-
dc.relation.journalEUROPEAN RESPIRATORY JOURNAL-
dc.contributor.googleauthorLee, Hyun-
dc.contributor.googleauthorRyu, Jiin-
dc.contributor.googleauthorNam, Eunwoo-
dc.contributor.googleauthorChung, Sung Jun-
dc.contributor.googleauthorYeo, Yoomi-
dc.contributor.googleauthorPark, Dong Won-
dc.contributor.googleauthorPark, Tai Sun-
dc.contributor.googleauthorMoon, Ji-Yong-
dc.contributor.googleauthorKim, Tae-Hyung-
dc.contributor.googleauthorSohn, Jang Won-
dc.relation.code2019002728-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.piddongwonpark-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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