Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜진 | - |
dc.date.accessioned | 2020-09-14T01:51:09Z | - |
dc.date.available | 2020-09-14T01:51:09Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | CLINICAL BREAST CANCER, v. 20, no. 1, Page. 51-60 | en_US |
dc.identifier.issn | 1526-8209 | - |
dc.identifier.issn | 1938-0666 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1526820919306846?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/153852 | - |
dc.description.abstract | With the development of imaging technologies, supraclavicular (SCN) and/or internal mammary nodes are increasingly detected in locally advanced breast cancers. The impact of aggressive treatment such as SCN excision was investigated via a large-scale multicenter study. When breast surgery, systemic therapy, and adjuvant radiotherapy were given, SCN excision did not improve locoregional control or survival. Introduction: The purpose of this study was to evaluate the outcomes of upfront surgery followed by radiation therapy (RT) for ipsilateral supraclavicular (SCN) and/or internal mammary (IMN) node-positive breast cancer. Materials and Methods: One hundred fifty-eight patients were included; among these, 91 patients were SCN-positive, 54 were IMN-positive, and 13 were SCN- and IMN-positive. Patients underwent breast conserving surgery (n = 74) or mastectomy (n = 84) followed by systemic therapy, and adjuvant RT to whole breast/chest wall with or without regional nodal RT. Regarding regional treatments for SCN and IMN, SCN excision was performed in 59 (37.3%) patients, IMN excision in 10 (6.3%) patients, SCN RT in 143 (90.5%) patients, and IMN RT in 68 (43.0%) patients. Results: The median duration of follow-up was 72 months (range, 7-182 months). There were 20 locoregional recurrences and 45 distant metastases. In-field failure was observed only in SCN (n = 8), and 6 of these patients initially underwent SCN excision. The 5-year locoregional recurrence-free survival, disease-free survival (DFS), and overall survival rates were 87.3%, 71.6%, and 89.7%, respectively. Neither SCN excision nor SCN RT dose >= 54 Gy improved locoregional control (P = .927 and P = .693, respectively) or DFS (P = .394 and P = .686, respectively). Having >= 10 involved axillary lymph nodes was the only independent prognosticator for DFS after adjusting for covariates (P = .003). Conclusion: Regional control rate in initially involved SCN and/or IMN was acceptable in patients treated with upfront surgery followed by systemic therapy plus adjuvant RT. More aggressive regional therapy such as SCN excision did not improve locoregional control or survival. | en_US |
dc.language.iso | en | en_US |
dc.publisher | CIG MEDIA GROUP | en_US |
dc.subject | Internal mammary node | en_US |
dc.subject | Non-axillary regional lymph node | en_US |
dc.subject | Prognostic factors | en_US |
dc.subject | Radiation therapy | en_US |
dc.subject | Upfront surgery | en_US |
dc.title | Aggressive Surgical Excision of Supraclavicular Lymph Node Did Not Improve the Outcomes of Breast Cancer With Supraclavicular Lymph Node Involvement (KROG 16-14) | en_US |
dc.type | Article | en_US |
dc.relation.no | epub | - |
dc.relation.volume | epub | - |
dc.identifier.doi | 10.1016/j.clbc.2019.09.004 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | CLINICAL BREAST CANCER | - |
dc.contributor.googleauthor | Kim, Kyubo | - |
dc.contributor.googleauthor | Kim, Su Ssan | - |
dc.contributor.googleauthor | Shin, Kyung Hwan | - |
dc.contributor.googleauthor | Kim, Jin Ho | - |
dc.contributor.googleauthor | Ahn, Seung Do | - |
dc.contributor.googleauthor | Choi, Doo Ho | - |
dc.contributor.googleauthor | Park, Won | - |
dc.contributor.googleauthor | Lee, Sun Young | - |
dc.contributor.googleauthor | Chun, Mison | - |
dc.contributor.googleauthor | Park, Hae Jin | - |
dc.relation.code | 2019043975 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | haejinpark | - |
dc.identifier.orcid | https://orcid.org/0000-0003-3891-8952 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.