100 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이정일-
dc.date.accessioned2020-09-08T04:32:51Z-
dc.date.available2020-09-08T04:32:51Z-
dc.date.issued2019-08-
dc.identifier.citationMUSCLE & NERVE, v. 60, no. 2, Page. 192-201en_US
dc.identifier.issn0148-639X-
dc.identifier.issn1097-4598-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/mus.26516-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/153656-
dc.description.abstractIntroduction We recently demonstrated the beneficial effects of 4-aminopyridine (4-AP), a potassium channel blocker, in enhancing remyelination and recovery of nerve conduction velocity and motor function after sciatic nerve crush injury in mice. Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4-AP on muscle atrophy and intrinsic muscle contractile function is largely unknown. Methods Mice were assigned to sciatic nerve crush injury and no-injury groups and were followed for 3, 7, and 14 days with/without 4-AP or saline treatment. Morphological, functional, and transcriptional properties of skeletal muscle were assessed. Results In addition to improving in vivo function, 4-AP significantly reduced muscle atrophy with increased muscle fiber diameter and contractile force. Reduced muscle atrophy was associated with attenuated expression of atrophy-related genes and increased expression of proliferating stem cells. Discussion These findings provide new insights into the potential therapeutic benefits of 4-AP against nerve injury-induced muscle atrophy and dysfunction. Muscle Nerve 60: 192-201, 2019en_US
dc.description.sponsorshipNational Institutes of Health (K08 AR060164-01A); Department of Defense (W81XWH-16-1-0725); University of Rochester Medical Center; Pennsylvania State University Medical Center.en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.subject4-aminopyridineen_US
dc.subjectatrophy-related genesen_US
dc.subjectmouseen_US
dc.subjectmuscle atrophyen_US
dc.subjectmuscle forceen_US
dc.subjectsciatic nerveen_US
dc.title4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in miceen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume60-
dc.identifier.doi10.1002/mus.26516-
dc.relation.page192-201-
dc.relation.journalMUSCLE & NERVE-
dc.contributor.googleauthorYue, Li-
dc.contributor.googleauthorTalukder, M. A. Hassan-
dc.contributor.googleauthorGurjar, Anagha-
dc.contributor.googleauthorLee, Jung Il-
dc.contributor.googleauthorNoble, Mark-
dc.contributor.googleauthorDirksen, Robert T.-
dc.contributor.googleauthorChakkalakal, Joe-
dc.contributor.googleauthorElfar, John C.-
dc.relation.code2019002449-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidosjungil-
dc.identifier.orcidhttps://orcid.org/0000-0002-1110-5030-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE