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4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice

Title
4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice
Author
이정일
Keywords
4-aminopyridine; atrophy-related genes; mouse; muscle atrophy; muscle force; sciatic nerve
Issue Date
2019-08
Publisher
WILEY
Citation
MUSCLE & NERVE, v. 60, no. 2, Page. 192-201
Abstract
Introduction We recently demonstrated the beneficial effects of 4-aminopyridine (4-AP), a potassium channel blocker, in enhancing remyelination and recovery of nerve conduction velocity and motor function after sciatic nerve crush injury in mice. Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4-AP on muscle atrophy and intrinsic muscle contractile function is largely unknown. Methods Mice were assigned to sciatic nerve crush injury and no-injury groups and were followed for 3, 7, and 14 days with/without 4-AP or saline treatment. Morphological, functional, and transcriptional properties of skeletal muscle were assessed. Results In addition to improving in vivo function, 4-AP significantly reduced muscle atrophy with increased muscle fiber diameter and contractile force. Reduced muscle atrophy was associated with attenuated expression of atrophy-related genes and increased expression of proliferating stem cells. Discussion These findings provide new insights into the potential therapeutic benefits of 4-AP against nerve injury-induced muscle atrophy and dysfunction. Muscle Nerve 60: 192-201, 2019
URI
https://onlinelibrary.wiley.com/doi/full/10.1002/mus.26516https://repository.hanyang.ac.kr/handle/20.500.11754/153656
ISSN
0148-639X; 1097-4598
DOI
10.1002/mus.26516
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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