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Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjögren’s syndrome: data from a nationwide cohort for Sjögren’s syndrome in Korea

Title
Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjögren’s syndrome: data from a nationwide cohort for Sjögren’s syndrome in Korea
Author
성윤경
Keywords
Sjögren’s syndrome; Ro antibody; minor salivary glands
Issue Date
2019-08
Publisher
CLINICAL & EXPER RHEUMATOLOGY
Citation
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, no. 3, Suppl.118, Page. 107-113
Abstract
Objective. To investigate clinical characteristics of patients with primary Sjögren's syndrome (SS) who were negative for anti-Ro/SSA antibody but positive for minor salivary gland biopsy (MSGB) compared to patients who presented positivity for anti-Ro/SSA antibody. Methods. The data of 355 patients from the Korean Initiative of primary Sjögren's Syndrome (KISS), a nationwide prospective cohort for primary SS in Korea, were analysed. All patients fulfilled the 2016 American College of Rheumatology/European League Against Rheumatism (EULAR) classification criteria. Of these patients, 326 were positive for anti-Ro/SSA antibody and 29 were antibody-negative, although they had positive findings in MSGB. Various clinical features including all kinds of tests for evaluating secretory function, disease-related clinical indices and serological values available in the cohort were compared between the two groups. Results. The anti-Ro/SSA-negative group showed less rheumatoid factor positivity (p<0.001), leucopenia (p=0.003), hypergammaglobulinaemia (p<0.001), lower serum ß2-microglobulin level (p=0.034), more anti-centromere antibody positivity (p<0.001), higher score in dryness domain of EULAR SS patient-reported index (p=0.048) and more positivity for peripheral nervous system domain in EULAR SS disease activity index and loss of teeth in SS disease damage index (p=0.021 and 0.041, respectively) than patients who were positive for anti-Ro/ SSA antibody. Conclusion. Primary SS patients who are negative for anti-Ro/SSA antibody have different clinical characteristics compared to patients who are positive for such antibody in Korea. Therefore, clinicians should consider MSGB in patients with suspicious symptoms who are anti-Ro/SSA-negative. © COPYRIGHT CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2019.
URI
https://www.clinexprheumatol.org/article.asp?a=14395https://repository.hanyang.ac.kr/handle/20.500.11754/153643
ISSN
0392-856X; 1593-098X
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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