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Analysis of Passive Mixing Behavior in a Poly(dimethylsiloxane) Microfluidic Channel Using Confocal Fluorescence and Raman Microscopy

Title
Analysis of Passive Mixing Behavior in a Poly(dimethylsiloxane) Microfluidic Channel Using Confocal Fluorescence and Raman Microscopy
Author
이은규
Keywords
Confocal Raman microscopy,; PDMS, Laminar flow mixing; Confocal fluorescence microscopy; Poly(dimethylsiloxane); Microfluidic channel
Issue Date
2004-10
Publisher
Applied Spectroscopy
Citation
Applied Spectroscopy. v. 58. No.10, Page. 1172-1179
Abstract
Confocal fluorescence microscopy (CFM) and confocal Raman microscopy (CRM) have been applied to monitor the laminar flow mixing behavior in a poly(dimethylsiloxane) (PDMS) microfluidic channel. Two passive PDMS micromixing devices were fabricated for this purpose: a two-dimensional round-wave channel and a three-dimensional serpentine channel. The microscale laminar flow mixing of ethanol and isopropanol was evaluated using the CFM and CRM at various flow rates. The mixing behavior of confluent streams in the microchannel was assessed by determining the degree of color change in Rhodamine 6G dye on mixing using the CFM. However, it was also possible to quantitatively evaluate the mixing process without employing a fluorescence label using the CRM. The results show a strong potential for CRM as a highly sensitive detection tool to measure fundamental fluid mixing processes and to provide detailed information on chemical changes of non-fluorescent reaction mixtures in a PDMS microfluidic channel.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/153608
ISSN
00037028
DOI
10.1366/0003702042336019
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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