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dc.contributor.author강보승-
dc.date.accessioned2020-09-03T07:54:34Z-
dc.date.available2020-09-03T07:54:34Z-
dc.date.issued2019-10-
dc.identifier.citationMOLECULAR MEDICINE REPORTS, v. 20, no. 4, Page. 3215-3223en_US
dc.identifier.issn1791-2997-
dc.identifier.issn1791-3004-
dc.identifier.urihttps://www.spandidos-publications.com/10.3892/mmr.2019.10560-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/153544-
dc.description.abstractIn 2013, WHO estimated that approximately 235 million people suffered from asthma worldwide. Asthma is a hyper responsive disorder, which is related to an imbalance between the T-helper type 1 and 2 cells (henceforth, Th1 and Th2, respectively). Allium hookeri is a plant that is widely used for culinary purposes and also in traditional Asian medicine. The present study was conducted to elucidate the anti-asthmatic effects and mechanism of action of A. hookeri root extracts (AHRE) in an ovalbumin (OVA)-induced asthma mouse model. The mice were divided into five groups, namely, the control, the OVA-treated group, the dexamethasone-treated group, the 30 mg/kg AHRE-treated group, and the 300 mg/kg AHRE-treated group. The total WBC count and the differential cell count in the bronchoalveolar fluid, the level of serum IgE, the histopathological changes in the lung, and changes in the cell surface molecules, the asthma-related cytokine levels, and Th cell transcription factors were evaluated. AHRE significantly ameliorated asthmatic changes, such as the total WBC count, eosinophil count, and the level of IgE; in addition, it reduced mucus hypersecretion, epithelial hyperplasia, and eosinophil infiltration in the lungs. AHRE significantly inhibited the expression of CD68(+) cells and MHC class II+ molecules, Th1 cell transcription factor (T-bet) activation, Th2 cell transcription factor (GATA-3) activation, and TNF-alpha in the lung tissue. Furthermore, it suppressed cell surface molecules, such as CD4(+)and CD8(+); Th1-related cytokines, such as IFN-gamma and IL-12p40; Th2-related cytokines, such as IL-4 and IL-5; and Th17-related cytokines, such as IL-6 and TNF-alpha, in a dose-dependent manner. Thus, AHRE may be considered a promising anti-asthmatic drug.en_US
dc.language.isoenen_US
dc.publisherSPANDIDOS PUBL LTDen_US
dc.subjectAllium hookerien_US
dc.subjectovalbumin-induced asthmaen_US
dc.subjectCD68en_US
dc.subjectMHC class IIen_US
dc.subjectTNF-alphaen_US
dc.titleAllium hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2-related factors in an ovalbumin-induced asthma mouse modelen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume20-
dc.identifier.doi10.3892/mmr.2019.10560-
dc.relation.page3215-3223-
dc.relation.journalMOLECULAR MEDICINE REPORTS-
dc.contributor.googleauthorBok, So-Hyeon-
dc.contributor.googleauthorSeo, Ji-Hye-
dc.contributor.googleauthorBae, Chun-Sik-
dc.contributor.googleauthorKang, Bossng-
dc.contributor.googleauthorCho, Seung Sik-
dc.contributor.googleauthorPark, Dae-Hun-
dc.relation.code2019044466-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidolivertw-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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