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Rate of three-dimensional neuroretinal rim thinning in glaucomatous eyes with optic disc haemorrhage

Title
Rate of three-dimensional neuroretinal rim thinning in glaucomatous eyes with optic disc haemorrhage
Author
이원준
Keywords
glaucoma; imaging; optic nerve
Issue Date
2020-05
Publisher
BMJ PUBLISHING GROUP
Citation
BRITISH JOURNAL OF OPHTHALMOLOGY, v. 104, no. 5, Page. 648-654
Abstract
Background To investigate the thinning rate of three-dimensional neuroretinal rim thickness (3D-NRT) in glaucoma eyes with optic disc haemorrhage (DH) and its relationship to retinal nerve fibre layer thickness (RNFLT) progression. Methods Ninety-five (95) eyes of 95 glaucoma patients with initial DH in the inferotemporal (n=69) and superotemporal (n=26) regions and 48 eyes of 48 glaucoma patients without DH were retrospectively reviewed. The rates of change for 3D-NRT and RNFLT were compared by linear mixed-effect model. For the direct comparison between 3D-NRT and RNFLT, dynamic-range-based normalised coefficient was used. The effect of DH frequency on the rates of thinning of 3D-NRT and RNFLT was evaluated. Results During a mean 7-year follow-up, the rates of thinning of 3D-NRT (-5.69 +/- 4.88 mu m/year) and RNFLT (-2.03 +/- 2.03 mu m/year) at 7 o'clock were faster than those at other locations (all p<0.05) in DH eyes. The dynamic-range-based normalised rate of thinning was significantly faster for RNFLT (-2.06%+/- 1.62%/year) than for 3D-NRT (-1.15%+/- 1.10%/year, p<0.001) in DH eyes, but not in non-DH eyes (p=0.43). DH frequency in the inferotemporal region was associated with the thinning rate of 3D-NRT as well as RNFLT. Conclusion DH eyes are associated with the progression of both 3D-NRT and RNFLT, especially in the inferotemporal region. DH eyes show a relatively faster thinning rate of average RNFLT than 3D-NRT. The frequency of DH can affect the progression of 3D-NRT as well as RNFLT.
URI
https://bjo.bmj.com/content/104/5/648https://repository.hanyang.ac.kr/handle/20.500.11754/153534
ISSN
0007-1161; 1468-2079
DOI
10.1136/bjophthalmol-2018-313595
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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