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Alterations in glucose metabolism in Vibrio cholerae serogroup O1 El Tor biotype strains

Title
Alterations in glucose metabolism in Vibrio cholerae serogroup O1 El Tor biotype strains
Author
이동현
Alternative Author(s)
이동현
Advisor(s)
김동욱
Issue Date
2020-08
Publisher
한양대학교
Degree
Master
Abstract
The 2 biotypes of Vibrio cholerae O1 serogroup strains-classical and El Tor-use glucose in distinct ways. Classical biotype strains perform organic acid-producing fermentation and eventually lose viability due to the self-induced creation of an acidic environment, whereas El Tor biotype strains use an alternative neutral fermentation pathway, which confers them with survival advantages. However, the neutral fermentation pathway was recruited only from prototype Wave 1 El Tor biotype strains, which have not been isolated since the mid-1990s. Current Wave 2 and Wave 3 atypical El Tor strains contain a single-base deletion in a gene that directs bacteria toward neutral fermentation, resulting in the loss of neutral fermentation and an appearance that is similar to classical biotype strains. Moreover, when sufficient glucose was supplied, Wave 1 El Tor strains maintained their use of acid-producing fermentation, in parallel with neutral fermentation, and thus lost viability in the late stationary phase. The global replacement of Wave 1 El Tor strains by Wave 2 and 3 atypical El Tor strains implies that the acidic fermentation pathway may not be disadvantageous to V. cholerae. The characteristics described in this manuscript might be applied to oral rehydration to improve the treatment of cholera.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/153088http://hanyang.dcollection.net/common/orgView/200000438026
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > PHARMACY(약학과) > Theses (Master)
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