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A single class of visual neurons drive avoidance flight turns in response to both approaching or horizontally moving objects

Title
A single class of visual neurons drive avoidance flight turns in response to both approaching or horizontally moving objects
Author
박하윤
Alternative Author(s)
박하윤
Advisor(s)
김안모
Issue Date
2020-08
Publisher
한양대학교
Degree
Master
Abstract
Visual object detection is crucial for the following behaviors in diverse animal species, including fruit flies: avoiding threats, foraging, and mating. Especially, detecting a looming predator and responding incorrect manner is one of the most critical visuomotor function for survival. Loom detecting neurons have been studied previously in various animals including Drosophila melanogaster. A recent study shows that LPLC2 and LC4 visual neurons respond to a looming pattern in a walking or resting fly. They directly activate the giant fiber descending neurons, which trigger the escape jump for taking-off. For specimens in flight, however, it is unclear which neurons mediate loom-induced escape flight maneuvers. Furthermore, in the case of flying Drosophila, similar escape maneuvers are shown to be executed in response to small horizontally moving objects. However, the neural circuit underneath it remains to be studied. Using thermogenetic inactivation and optogenetic activation screening in conjunction with in-vivo calcium-imaging experiments, we studied visual neurons that were important for visually induced escape flight turns. In particular, we show that LPLC2 neurons respond both to a looming and horizontally moving object and induce escape turns in flying Drosophila. It defines these neurons as an escape-inducing neuron in response to multiple visual features. We also show that the two distinct visual features –– a loom and a horizontally moving spot –– arrive at LPLC2 neurons from two distinct visual structures: the lobula plate for the looming pattern and the lobula for the horizontally moving spot. Together, our findings highlight a shared use of a single class of sensory neurons in multiple motor contexts –– in flight and walking –– as well as in response to multiple visual patterns that are required to cause motor actions of similar characteristics.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/153048http://hanyang.dcollection.net/common/orgView/200000438040
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIOMEDICAL ENGINEERING(생체공학과) > Theses (Master)
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