Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손현 | - |
dc.date.accessioned | 2020-08-24T07:12:43Z | - |
dc.date.available | 2020-08-24T07:12:43Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | EXPERIMENTAL NEUROBIOLOGY, v. 28, no. 4, Page. 537-546 | en_US |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.uri | http://www.en-journal.org/journal/view.html?doi=10.5607/en.2019.28.4.537 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/152450 | - |
dc.description.abstract | Silent information regulator 2 (Sirtuin2 / SIRT2) is a NAD(+)-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins including histones. Previous studies have shown that SIRT2 plays a role in mood disorders and hippocampus-dependent cognitive function, but the underlying neurobiological mechanism is poorly understood. Here, we report that chronic stress suppresses SIRT2 expression in the hippocampus. Molecular and biochemical analyses indicate that the stress-induced decrease in the SIRT2 expression downregulates synaptic plasticity-related genes in the hippocampus through the increase of euchromatic histone-lysine N-methyltransferase 2 (Ehmt2) (also known as G9a). shRNA-mediated knockdown of SIRT2 in the dentate gyrus alters the expression of synaptic plasticity-related genes in a way similar to those induced by chronic stress, and produces depression-like behaviors. Our results indicate that SIRT2 plays an important role in the response to stress, thereby modulating depression-like behaviors. | en_US |
dc.description.sponsorship | This work was supported by a National Research Foundation of Korea (NRF) grant (No. 2019R1A2C2003616 to H.S.), a Medical Research Center Grant (2017R1A5A2015395 to H.S.) and a Basic Science Research Program Grant (No. 2017R1A6A3A01005765 to S.E.W.) funded by the Ministry of Science and Technology (MEST), Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC BRAIN & NEURAL SCIENCE | en_US |
dc.subject | SIRT2 | en_US |
dc.subject | depression | en_US |
dc.subject | Ehmt2 | en_US |
dc.subject | Synaptic plasticity | en_US |
dc.subject | Hippocampus | en_US |
dc.title | Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2 | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.5607/en.2019.28.4.537 | - |
dc.relation.page | 537-546 | - |
dc.relation.journal | EXPERIMENTAL NEUROBIOLOGY | - |
dc.contributor.googleauthor | Wang, Sung Eun | - |
dc.contributor.googleauthor | Ko, Seung Yeon | - |
dc.contributor.googleauthor | Jo, Sungsin | - |
dc.contributor.googleauthor | Jo, Hye-Ryeong | - |
dc.contributor.googleauthor | Han, Jinil | - |
dc.contributor.googleauthor | Kim, Yong-Seok | - |
dc.contributor.googleauthor | Son, Hyeon | - |
dc.relation.code | 2019042945 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyeonson | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.