Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민경 | - |
dc.date.accessioned | 2020-08-24T04:43:05Z | - |
dc.date.available | 2020-08-24T04:43:05Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | DIABETES CARE, v. 42, no. 7, Page. 1217-1224 | en_US |
dc.identifier.issn | 0149-5992 | - |
dc.identifier.issn | 1935-5548 | - |
dc.identifier.uri | https://care.diabetesjournals.org/content/42/7/1217 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/152437 | - |
dc.description.abstract | OBJECTIVE This study examined the association between baseline BMI, percentage weight change, and the risk of dementia in patients newly diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS Using the South Korean National Health Insurance Service-National Health Screening Cohort database, we identified 167,876 subjects aged >= 40 years diagnosed with new-onset type 2 diabetes between 2007 and 2012. Their weight changes were monitored for similar to 2 years after diagnosis, with follow-up assessments occurring for an average of 3.5 years. The hazard ratios (HRs) and Bonferroni-adjusted 95% CIs of all-cause dementia, Alzheimer disease (AD), and vascular dementia were estimated using multivariable Cox proportional hazards regression models. RESULTS We identified 2,563 incident dementia cases during follow-up. Baseline BMI among patients with new-onset type 2 diabetes was inversely associated with the risk of all-cause dementia and AD, independent of confounding variables (P for trend <0.001). The percentage weight change during the 2 years after a diagnosis of type 2 diabetes showed significant U-shaped associations with the risk of all-cause dementia development (P < 0.001); the HRs of the disease increased significantly when weight loss or gain was >10% (1.34 [95% CI 1.11-1.63] and 1.38 [1.08-1.76], respectively). Additionally, weight loss >10% was associated with an increased risk of AD (HR 1.26 [95% CI 1.01-1.59]). CONCLUSIONS A lower baseline BMI was associated with increased risks of all-cause dementia and AD in patients with new-onset type 2 diabetes. Weight loss or weight gain after the diagnosis of diabetes was associated with an increased risk of all-cause dementia. Weight loss was associated with an increased risk of AD. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2018R1D1A1B07049079). | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER DIABETES ASSOC | en_US |
dc.subject | BODY-MASS INDEX | en_US |
dc.subject | MILD COGNITIVE IMPAIRMENT | en_US |
dc.subject | ALZHEIMERS-DISEASE | en_US |
dc.subject | OBESE INDIVIDUALS | en_US |
dc.subject | LATE-LIFE | en_US |
dc.subject | MELLITUS | en_US |
dc.subject | MIDLIFE | en_US |
dc.subject | ASSOCIATION | en_US |
dc.subject | PROGRESSION | en_US |
dc.subject | ADIPOSITY | en_US |
dc.title | BMI, Weight Change, and Dementia Risk in Patients With New-Onset Type 2 Diabetes: A Nationwide Cohort Study | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2337/dc18-1667 | - |
dc.relation.journal | DIABETES CARE | - |
dc.contributor.googleauthor | Nam, Ga Eun | - |
dc.contributor.googleauthor | Park, Yong Gyu | - |
dc.contributor.googleauthor | Han, Kyungdo | - |
dc.contributor.googleauthor | Kim, Mee Kyoung | - |
dc.contributor.googleauthor | Koh, Eun Sil | - |
dc.contributor.googleauthor | Kim, Eun Sook | - |
dc.contributor.googleauthor | Lee, Min-Kyung | - |
dc.contributor.googleauthor | Kim, Bongsung | - |
dc.contributor.googleauthor | Hong, Oak-Kee | - |
dc.contributor.googleauthor | Kwon, Hyuk-Sang | - |
dc.relation.code | 2019000794 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | min7949 | - |
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