87 0

Increased risk of opportunistic infection in early rheumatoid arthritis

Title
Increased risk of opportunistic infection in early rheumatoid arthritis
Author
조수경
Keywords
corticosteroid; disease-modifying antirheumatic drugs (biologic); opportunistic infections; rheumatoid arthritis
Issue Date
2019-07
Publisher
WILEY
Citation
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 22, no. 7, Page. 1239-1246
Abstract
Aim To estimate incidence rate (IR) and risk factors for opportunistic infections (OI) in early rheumatoid arthritis (RA) patients. Methods Retrospective cohorts were identified in the Korean National Claims Database. Incident RA cases were recruited in 2010 (n = 14 081). Follow up was ended at the time of development of new OI or at the date of last visit within 12 months of diagnosis. The IR and standardized incidence ratio (SIR) of OI in early and overall RA (n = 226 838) over a year were calculated. A multivariable regression model was used to identify risk factors for OI in early RA. Results The IR of OI in early and overall RA were 3.81/100 and 3.67/100 person-years, respectively. The SIR for OI in early RA was 1.14 (95% CI, 1.05-1.23). Herpes zoster (SIR = 1.12, 95% CI, 1.03-1.22) and candidiasis (SIR = 2.40, 95% CI, 1.55-3.54) were common in early RA. Age (50 ˂ age ˂= 60 [OR 1.74, 95% CI, 1.30-2.33], 60 ˂ age ˂= 70 [OR 1.85, 95% CI, 1.36-2.52], age ˃ 70 [OR 1.89, 95% CI, 1.34-2.68]), female sex (OR 1.40, 95% CI, 1.12-1.74), comorbidities (one comorbidity [OR 1.53, 95% CI, 1.24-1.89], ˃= two comorbidities [OR 1.84, 95% CI, 1.47-2.29]), and corticosteroid use of 5 mg/d or more (OR 1.38, 95% CI, 1.13-1.69) were significantly associated with increased risk of OI in early RA. Conclusion Opportunistic infections, especially for herpes zoster and candidiasis, tend to occur more often in early RA than in overall RA. Age, female sex, comorbidities and corticosteroid use are related to increased OI in early RA patients.
URI
https://onlinelibrary.wiley.com/doi/full/10.1111/1756-185X.13585https://repository.hanyang.ac.kr/handle/20.500.11754/152355
ISSN
1756-1841; 1756-185X
DOI
10.1111/1756-185X.13585
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE