Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성윤경 | - |
dc.date.accessioned | 2020-08-19T05:51:11Z | - |
dc.date.available | 2020-08-19T05:51:11Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | 대한류마티스학회지, v. 26, no. 3, Page. 179-185 | en_US |
dc.identifier.issn | 2093-940X | - |
dc.identifier.issn | 2233-4718 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4078/jrd.2019.26.3.179 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/152353 | - |
dc.description.abstract | Objective. To evaluate the nonsteroidal anti-inflammatory drugs (NSAID)-sparing effect of symptomatic slow-acting drugs for osteoarthritis (SYSADOA) in knee osteoarthritis (OA) patients. Methods. A retrospective study was conducted on a cohort of knee OA patients who visited a single academic referral hospital from 2013 to 2014. Among all patients, NSAID users in their first visit were extracted and divided into SYSADOA users and SYSADOA non-users. All patients were observed from their first visit with knee OA to their last visit, NSAID discontinuation, or the date of data collection, July 2017 (mean observational periods: 369.1 days). To evaluate the NSAID-sparing effect of SYSADOA, Cox regression analysis was performed after adjusting for confounding factors. Results. Patients for this study (n=212) were divided into SYSADOA users (n=57) and SYSADOA non-users (n=155). The mean age (68.8 vs. 66.6 years old, p=0.31) and the number of comorbidities (p=0.73) were comparable between the two groups. The SYSADOA users showed higher Kellgren–Lawrence (KL) grade (66.7% of patients with more than KL grade 3) than SYSADOA non-users (42.6% of patients with more than KL grade 3) (p=0.02). In treatment, the frequency of intra-articular injection was higher in the SYSADOA user group than the SYSADOA non-user group (33.3% vs. 9.0%, p<0.01). In Cox regression analysis, SYSADOA use contributed to NSAID discontinuation in knee OA patients (hazard ratio 2.97, 95% confidential interval 1.42∼6.22). Conclusion. This real-world analysis demonstrated that SYSADOA use combined with NSAIDs had a significant effect on NSAID discontinuation in patients with knee OA. | en_US |
dc.description.sponsorship | This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HC15C3388). | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한류마티스학회 | en_US |
dc.subject | Osteoarthritis | en_US |
dc.subject | Symptomatic slow-acting drugs for osteoarthritis | en_US |
dc.subject | Nonsteroidal anti-inflammatory drugs | en_US |
dc.title | Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 26 | - |
dc.identifier.doi | 10.4078/jrd.2019.26.3.179 | - |
dc.relation.page | 179-185 | - |
dc.relation.journal | 대한류마티스학회지 | - |
dc.contributor.googleauthor | Cho, Soo-Kyung | - |
dc.contributor.googleauthor | Kim, Hyoungyoung | - |
dc.contributor.googleauthor | Park, Ha-Rim | - |
dc.contributor.googleauthor | Choi, Wooseok | - |
dc.contributor.googleauthor | Choi, Seongmi | - |
dc.contributor.googleauthor | Jung, Sun-Young | - |
dc.contributor.googleauthor | Jang, Eun Jin | - |
dc.contributor.googleauthor | Sung, Yoon-Kyoung | - |
dc.relation.code | 2019035259 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sungyk | - |
dc.identifier.orcid | https://orcid.org/0000-0001-6691-8939 | - |
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