90 0

Fe3O4-ZnO Core-Shell Nanoparticles Fabricated by Ultra-Thin Atomic Layer Deposition Technique as a Drug Delivery Vehicle

Title
Fe3O4-ZnO Core-Shell Nanoparticles Fabricated by Ultra-Thin Atomic Layer Deposition Technique as a Drug Delivery Vehicle
Author
이수재
Keywords
Core-shell; Nanoparticle; Atomic layer deposition; Drug delivery; Cell viability
Issue Date
2019-07
Publisher
KOREAN INST METALS MATERIALS
Citation
ELECTRONIC MATERIALS LETTERS, v. 15, no. 4, Page. 493-499
Abstract
Fe3O4-ZnO nanoparticles with core-shell structures were successfully fabricated by an atomic layer deposition method. The core-shell NPs consisted of superparamagnetic Fe3O4 cores of 100nm average size and conformal ZnO shells of 10nm thickness. The NPs showed a saturation magnetization of 23emu/g, which is suitable for magnetic delivery of the particles. Cytotoxicity testing revealed that the Fe3O4-ZnO NPs have high cell viability (over 90%) after 24h culture. Also, they exhibited a high ibuprofen-loading capacity (640g per mg of the particles) and good release ability (˃90% after 72h in simulated body fluid). As a result, the Fe3O4-ZnO nanoparticles with conformal ultra-thin ZnO shell layers are anticipated as promising drug delivery vehicles with acceptable cell viability and high drug loading-release abilities.
URI
https://link.springer.com/article/10.1007%2Fs13391-019-00147-6https://repository.hanyang.ac.kr/handle/20.500.11754/152338
ISSN
1738-8090; 2093-6788
DOI
10.1007/s13391-019-00147-6
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE