Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박현경 | - |
dc.date.accessioned | 2020-08-19T00:36:38Z | - |
dc.date.available | 2020-08-19T00:36:38Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 60, no. 8, Page. 3024-3033 | en_US |
dc.identifier.issn | 0146-0404 | - |
dc.identifier.issn | 1552-5783 | - |
dc.identifier.uri | http://iovs.arvojournals.org/article.aspx?articleid=2738360 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/152328 | - |
dc.description.abstract | PURPOSE. To investigate white matter maturation in preterm infants with and without retinopathy of prematurity (ROP) and to determine whether ROP is associated with white matter microstructural integrity at term-equivalent ages. METHODS. In 82 preterm and 34 full-term infants who had undergone brain magnetic resonance imaging diffusion tensor imaging at term-equivalent ages, white matter microstructural integrity was assessed based on mean fractional anisotropy (FA) and mean diffusivity (MD) values in 23 predefined regions of interest by using atlas-based analyses. The values were compared among preterm and full-term infants, and a general linear model was used to evaluate the association of the values with ROP or severe (i.e., stage ˃= 3) ROP. RESULTS. Significant differences in FA and MD values were observed among preterm and full-term infants in 17 (73.9%) and 15 (65.2%) of the 23 white matter areas evaluated, respectively. However, ROP was significantly associated with MD values in only two areas (superior longitudinal fasciculus [P = 0.030] and cerebral peduncle [P = 0.005]). Severe ROP was significantly associated with FA values within the anterior limb of the internal capsule (P = 0.049) and MD values within the stria terminalis (P = 0.035). A network analysis showed that preterm infants with severe ROP had lower small-world index values than those without. CONCLUSIONS. Preterm birth may be more strongly associated with white matter maturation at term-equivalent ages than ROP, but severe ROP may be associated with decreased structural connectivity. | en_US |
dc.description.sponsorship | Supported by the National Research Foundation of Korea Grant funded by the Korean Government MSIT (NRF-2017-R1C1B5015046) and the research fund of Hanyang University (HY-2018). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | en_US |
dc.subject | diffusion tensor imaging | en_US |
dc.subject | magnetic resonance imaging | en_US |
dc.subject | retinopathy of prematurity | en_US |
dc.subject | white matter | en_US |
dc.title | Diffusion Tensor Imaging Analysis of White Matter Microstructural Integrity in Infants With Retinopathy of Prematurity | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 60 | - |
dc.identifier.doi | 10.1167/iovs.18-25849 | - |
dc.relation.page | 3024-3033 | - |
dc.relation.journal | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | - |
dc.contributor.googleauthor | Ahn, Seong Joon | - |
dc.contributor.googleauthor | Park, Hyun-Kyung | - |
dc.contributor.googleauthor | Lee, Byung Ro | - |
dc.contributor.googleauthor | Lee, Hyun Ju | - |
dc.relation.code | 2019000567 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | neopark | - |
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